専任教員紹介

健康福祉学科長補佐

教授

柴原 茂樹

Shibahara Shigeki

医学博士 (東北大学)

研究領域

ライフサイエンス / 分子生物学 /

ライフサイエンス / 医化学 /

ライフサイエンス / 病態医化学 /

資格・免許

医師免許

日本医師会認定産業医

日本スポーツ協会公認スポーツドクター

論文 (235)

1.

Melanocytes contribute to the vasculature of the choroid.

Shibuya H , Watanabe R , Maeno A , Ichimura K , Tamura M , Wakana S , Shiroishi T , Ohba K , Takeda K , Tomita H , Shibahara S , Yamamoto H

Genes & Genetic Systems 93 (2) 51 - 58 2018

2.

Dysregulated Expression of MITF in Subsets of Hepatocellular Carcinoma and Cholangiocarcinoma

Nattakarn Nooron , Koji Ohba , Kazuhisa Takeda , Shigeki Shibahara , Anchalee Chiabchalard

The Tohoku Journal of Experimental Medicine 242 (4) 291 - 302 2017

3.

Tetrahydrocurcumin in combination with deferiprone attenuates hypertension, vascular dysfunction, baroreflex dysfunction, and oxidative stress in iron-overloaded mice

Weerapon Sangartit , Poungrat Pakdeechote , Veerapol Kukongviriyapan , Wanida Donpunha , Shigeki Shibahara , Upa Kukongviriyapan

Vascular Pharmacology 87 199 - 208 2016-12-01

4.

Microphthalmia-associated transcription factor ensures the elongation of axons and dendrites in the mouse frontal cortex

Koji Ohba , Kazuhisa Takeda , Tamio Furuse , Tomohiro Suzuki , Shigeharu Wakana , Takashi Suzuki , Hiroaki Yamamoto , Shigeki Shibahara

Genes to Cells 21 (12) 1365 - 1379 2016-12-01

5.

Regional fluctuation in the functional consequence of LINE-1 insertion in the Mitf gene: The black spotting phenotype arisen from the Mitfmi-bw mouse lacking melanocytes ラスト(シニア)オーサー / 責任著者

Kazuhisa Takeda , Hiroki Hozumi , Koji Ohba , Hiroaki Yamamoto , Shigeki Shibahara

PLoS ONE 11 (3) e0150228 - e0150228 2016-03-01

6.

Induction of MITF expression in human cholangiocarcinoma cells and hepatocellular carcinoma cells by cyclopamine, an inhibitor of the Hedgehog signaling

Papavee Samatiwat , Kazuhisa Takeda , Soisungwan Satarug , Koji Ohba , Veerapol Kukongviriyapan , Shigeki Shibahara

Biochemical and Biophysical Research Communications 470 (1) 144 - 149 2016-01-29

7.

Microphthalmia-associated transcription factor is expressed in projection neurons of the mouse olfactory bulb ラスト(シニア)オーサー / 責任著者

Koji Ohba , Kazuhisa Takeda , Hiroaki Yamamoto , Shigeki Shibahara

Genes to Cells 20 (12) 1088 - 1102 2015-12-01

8.

Microphthalmia-associated transcription factor as the molecular target of cadmium toxicity in human melanocytes ラスト(シニア)オーサー / 責任著者

Wipa Chantarawong , Kazuhisa Takeda , Weerapon Sangartit , Miki Yoshizawa , Kantimanee Pradermwong , Shigeki Shibahara

Biochemical and Biophysical Research Communications 454 (4) 594 - 599 2014-11-28

9.

Identification of a novel erythroid-specific enhancer for the ALAS2 gene and its loss-of-function mutation which is associated with congenital sideroblastic anemia

Kiriko Kaneko , Kazumichi Furuyama , Tohru Fujiwara , Ryoji Kobayashi , Hiroyuki Ishida , Hideo Harigae , Shigeki Shibahara

Haematologica 99 (2) 252 - 261 2014-02-01

10.

Insertion of long interspersed element-1 in the Mitf gene is associated with altered neurobehavior of the black-eyed white Mitfmi-bw mouse ラスト(シニア)オーサー

Kazuhisa Takeda , Hiroki Hozumi , Kunihiko Nakai , Miki Yoshizawa , Hiroshi Satoh , Hiroaki Yamamoto , Shigeki Shibahara

Genes to Cells 19 (2) 126 - 140 2014-02

11.

The Great East-Japan Earthquake and Devastating Tsunami: An Update and Lessons from the Past Great Earthquakes in Japan since 1923 ラスト(シニア)オーサー / 責任著者

Akemi Ishigaki , Hikari Higashi , Takako Sakamoto , Shigeki Shibahara

The Tohoku Journal of Experimental Medicine 229 (4) 287 - 299 2013

12.

Otx2 Is Involved in the Regional Specification of the Developing Retinal Pigment Epithelium by Preventing the Expression of Sox2 and Fgf8, Factors That Induce Neural Retina Differentiation

Daisuke Nishihara , Ichiro Yajima , Hiromasa Tabata , Masato Nakai , Nagaharu Tsukiji , Tatsuya Katahira , Kazuhisa Takeda , Shigeki Shibahara , Harukazu Nakamura , Hiroaki Yamamoto

PLoS ONE 7 (11) e48879 - e48879 2012-11-08

13.

Lipocalin-type prostaglandin D synthase as a marker for the proliferative potential of melanocyte-lineage cells in the human skin ラスト(シニア)オーサー / 責任著者

Miwa Shimanuki , Kazuhisa Takeda , Masakazu Kawaguchi , Tamio Suzuki , Shigeki Shibahara

Journal of Dermatology 39 (8) 699 - 704 2012-08

14.

The carboxyl-terminal region of erythroid-specific 5-aminolevulinate synthase acts as an intrinsic modifier for its catalytic activity and protein stability ラスト(シニア)オーサー

Senkottuvelan Kadirvel , Kazumichi Furuyama , Hideo Harigae , Kiriko Kaneko , Yoshiko Tamai , Yoji Ishida , Shigeki Shibahara

Experimental Hematology 40 (6) 477 - e1 2012-06

15.

Impaired development of melanoblasts in the black-eyed white Mitf mi-bw mouse, a model for auditory-pigmentary disorders ラスト(シニア)オーサー / 責任著者

Hiroki Hozumi , Kazuhisa Takeda , Yasuko Yoshida-Amano , Yuji Takemoto , Ryota Kusumi , Urara Fukuzaki-Dohi , Atsushi Higashitani , Hiroaki Yamamoto , Shigeki Shibahara

Genes to Cells 17 (6) 494 - 508 2012-06

16.

Revisiting the March 11, 2011 Earthquake and Tsunami: Resilience and Restoration 筆頭著者 / 責任著者

Shigeki Shibahara

The Tohoku Journal of Experimental Medicine 226 (1) 1 - 2 2012

17.

Coordinated expression of 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase 4 and heme oxygenase 2: Evidence for a regulatory link between glycolysis and heme catabolism

Bin Li , Kazuhisa Takeda , Kazunobu Ishikawa , Miki Yoshizawa , Michihiko Sato , Shigeki Shibahara , Kazumichi Furuyama

Tohoku Journal of Experimental Medicine 228 (1) 27 - 41 2012

18.

The 2011 Tohoku Earthquake and Devastating Tsunami 筆頭著者 / 責任著者

Shigeki Shibahara

The Tohoku Journal of Experimental Medicine 223 (4) 305 - 307 2011

19.

Lipocalin-type prostaglandin D synthase as a regulator of the retinoic acid signalling in melanocytes ラスト(シニア)オーサー / 責任著者

Kazuhisa Takeda , Na-Ho Takahashi , Miki Yoshizawa , Shigeki Shibahara

Journal of Biochemistry 148 (2) 139 - 148 2010-08

20.

Sensing the soul of science via Sendai: The prologue to the tenth decade of TJEM

Shigeki Shibahara

Tohoku Journal of Experimental Medicine 220 (1) 1 - 2 2010

21.

Hypoxemia induces expression of heme oxygenase-1 and heme oxygenase-2 proteins in the mouse myocardium ラスト(シニア)オーサー / 責任著者

Feng Han , Kazuhisa Takeda , Masao Ono , Fumiko Date , Kazunobu Ishikawa , Satoru Yokoyama , Yotaro Shinozawa , Kazumichi Furuyama , Shigeki Shibahara

Journal of Biochemistry 147 (1) 143 - 151 2010-01

22.

Functional expression of heme oxygenase-1 in human differentiated epidermis and its regulation by cytokines

Ikuko Numata , Ryuhei Okuyama , Ai Memezawa , Yumiko Ito , Kazuhisa Takeda , Kazumichi Furuyama , Shigeki Shibahara , Setsuya Aiba

Journal of Investigative Dermatology 129 (11) 2594 - 2603 2009-11

23.

Induction of lipocalin-type prostaglandin D synthase in mouse heart under hypoxemia ラスト(シニア)オーサー / 責任著者

Feng Han , Kazuhisa Takeda , Kazunobu Ishikawa , Masao Ono , Fumiko Date , Satoru Yokoyama , Kazumichi Furuyama , Yotaro Shinozawa , Yoshihiro Urade , Shigeki Shibahara

Biochemical and Biophysical Research Communications 385 (3) 449 - 453 2009-07-31

24.

MITF-CM, a newly identified isoform of microphthalmia-associated transcription factor, is expressed in cultured mast cells

M. Shiohara , T. Shigemura , T. Suzuki , M. Tanaka , E. Morii , H. Ohtsu , S. Shibahara , K. Koike

International Journal of Laboratory Hematology 31 (2) 215 - 226 2009-04

25.

Hypoxia induces erythroid-specific 5-aminolevulinate synthase expression in human erythroid cells through transforming growth factor-β signaling

Kiriko Kaneko , Kazumichi Furuyama , Hiroyuki Aburatani , Shigeki Shibahara

FEBS Journal 276 (5) 1370 - 1382 2009-03

26.

Mitf functions as an in ovo regulator for cell differentiation and proliferation during development of the chick RPE

Nagaharu Tsukiji , Daisuke Nishihara , Ichiro Yajima , Kazuhisa Takeda , Shigeki Shibahara , Hiroaki Yamamoto

Developmental Biology 326 (2) 335 - 346 2009-02-15

27.

Specific expression of Gsta4 in mouse cochlear melanocytes: A novel role for hearing and melanocyte differentiation

Shigeyuki Uehara , Yoshiko Izumi , Yuko Kubo , Chi Chiu Wang , Katsuhiko Mineta , Kazuho Ikeo , Takashi Gojobori , Masayoshi Tachibana , Toshihiko Kikuchi , Toshimitsu Kobayashi , Shigeki Shibahara , Choji Taya , Hiromichi Yonekawa , Toshihiko Shiroishi , Hiroaki Yamamoto

Pigment Cell and Melanoma Research 22 (1) 111 - 119 2009-02

28.

What are melanocytes really doing all day long...?

Przemyslaw M. Plonka , Thierry Passeron , Michaela Brenner , Desmond J. Tobin , Shigeki Shibahara , Aaron Thomas , Andrzej Slominski , Ana Luisa Kadekaro , Dov Hershkovitz , Eva M.J. Peters , James J. Nordlund , Zalfa Abdel-malek , Kazuhisa Takeda , Ralf Paus , Jean Paul Ortonne , Vincent J. Hearing , Karin U. Schallreuter

Experimental Dermatology 18 (9) 799 - 819 2009

29.

Prostaglandin D2 induces heme oxygenase-1 mRNA expression through the DP2 receptor ラスト(シニア)オーサー / 責任著者

Soisungwan Satarug , Raewadee Wisedpanichkij , Kazuhisa Takeda , Bin Li , Kesara Na-Bangchang , Michael R. Moore , Shigeki Shibahara

Biochemical and Biophysical Research Communications 377 (3) 878 - 883 2008-12-19

30.

Prevention of cadmium accumulation in retinal pigment epithelium with manganese and zinc ラスト(シニア)オーサー / 責任著者

Soisungwan Satarug , Mihoko Kikuchi , Raewadee Wisedpanichkij , Bin Li , Kazuhisa Takeda , Kesara Na-Bangchang , Michael R. Moore , Kenji Hirayama , Shigeki Shibahara

Experimental Eye Research 87 (6) 587 - 593 2008-12-10

31.

Hypoxia decreases the expression of the two enzymes responsible for producing linear and cyclic tetrapyrroles in the heme biosynthetic pathway ラスト(シニア)オーサー

Patrick D. Vargas , Kazumichi Furuyama , Shigeru Sassa , Shigeki Shibahara

FEBS Journal 275 (23) 5947 - 5959 2008-12

32.

A prolyl-hydroxylase inhibitor, ethyl-3,4-dihydroxybenzoate, induces haem oxygenase-1 expression in human cells through a mechanism independent of hypoxia-inducible factor-1α ラスト(シニア)オーサー / 責任著者

Bin Li , Kazuhisa Takeda , Satoru Yokoyama , Shigeki Shibahara

Journal of Biochemistry 144 (5) 643 - 654 2008-11

33.

Prostaglandin D2 induces heme oxygenase-1 in human retinal pigment epithelial cells ラスト(シニア)オーサー / 責任著者

Jiraporn Kuesap , Bin Li , Soisungwan Satarug , Kazuhisa Takeda , Ikuko Numata , Kesara Na-Bangchang , Shigeki Shibahara

Biochemical and Biophysical Research Communications 367 (2) 413 - 419 2008-03-07

34.

Synergistic activation of the human adrenomedullin gene promoter by Sp1 and AP-2 alpha

Yan Zhang , Yin Li , Shigeki Shibahara , Kazuhiro Takahashi

PEPTIDES 29 (3) 465 - 472 2008-03

35.

Hypoxia and heme oxygenases: Oxygen sensing and regulation of expression 筆頭著者 / 責任著者

Shigeki Shibahara , Feng Han , Bin Li , Kazuhisa Takeda

ANTIOXIDANTS & REDOX SIGNALING 9 (12) 2209 - 2225 2007-12

36.

Transcriptional Regulation of Melanocyte Function

Kazuhisa Takeda , Shigeki Shibahara

The Pigmentary System: Physiology and Pathophysiology: Second Edition 242 - 260 2007-10-26

37.

Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes

Jianyong Zhang , Tomonori Hosoya , Atsushi Maruyama , Keizo Nishikawa , Jonathan M. Maher , Tsutomu Ohta , Hozumi Motohashi , Akiyoshi Fukamizu , Shigeki Shibahara , Ken Itoh , Masayuki Yamamoto

BIOCHEMICAL JOURNAL 404 (3) 459 - 466 2007-06

38.

Adrenomedullin is a novel adipokine: Adrenomedullin in adipocytes and adipose tissues

Yin Li , Changtao Jiang , Xian Wang , Yan Zhang , Shigeki Shibahara , Kazuhiro Takahashi

PEPTIDES 28 (5) 1129 - 1143 2007-05

39.

Neuroendocrine functions of melanocytes: Beyond the skin-deep melanin maker

Kazuhisa Takeda , Na-Ho Takahashi , Shigeki Shibahara

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 211 (3) 201 - 221 2007-03

40.

Augmented chemosensitivity in black-eyed white Mitf(mi-bw) mice, lacking melanocytes

Kazuhisa Takeda , Tetsuya Adachi , Feng Han , Satoru Yokoyama , Hiroaki Yamamoto , Wataru Hida , Shigeki Shibahara

JOURNAL OF BIOCHEMISTRY 141 (3) 327 - 333 2007-03

41.

Down-regulation of heme oxygenase-2 is associated with the increased expression of heme oxygenase-1 in human cell lines ラスト(シニア)オーサー / 責任著者

Yuanying Ding , Yong Z. Zhang , Kazumichi Furuyama , Kazuhiro Ogawa , Kazuhiko Igarashi , Shigeki Shibahara

FEBS JOURNAL 273 (23) 5333 - 5346 2006-12

42.

BRG1 interacts with Nrf2 to selectively mediate HO-1 induction in response to oxidative stress

Jianyong Zhang , Tsutomu Ohta , Atsushi Maruyama , Tomonori Hosoya , Keizo Nishikawa , Jonathan A. Maher , Shigeki Shibahara , Ken Itoh , Masayuki Yamamoto

MOLECULAR AND CELLULAR BIOLOGY 26 (21) 7942 - 7952 2006-11

43.

Hypoxia increases endothelin-1 mRNA expression but not immunoreactive endothelin in the medium of T98G glioblastoma cells under cytokine treatment

Yan Zhang , Yin Li , Kazuhito Totsune , Kumi Kikuchi , Osamu Murakami , Shigeki Shibahara , Kazuhiro Takahashi

PEPTIDES 27 (11) 3003 - 3006 2006-11

44.

Adrenomedullin in adipocyte differentiation of human mesenchymal stem cells

Yin Li , Yan Zhang , Shigeki Shibahara , Kazuhiro Takahashi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 350 (3) 616 - 622 2006-11

45.

Functional difference of the SOX10 mutant proteins responsible for the phenotypic variability in auditory-pigmentary disorders

Satoru Yokoyama , Kazuhisa Takeda , Shigeki Shibahara

Journal of Biochemistry 140 (4) 491 - 499 2006-10

46.

Hypoxia reduces the expression of heme oxygenase-2 in various types of human cell lines - A possible strategy for the maintenance of intracellular heme level

Yongzhao Zhang , Kazumichi Furuyama , Kiriko Kaneko , Yuanying Ding , Kazuhiro Ogawa , Miki Yoshizawa , Masaki Kawamura , Kazuhisa Takeda , Tadashi Yoshida , Shigeki Shibahara

FEBS JOURNAL 273 (14) 3136 - 3147 2006-07

47.

Mice with blunted hypoxic ventilatory response are susceptible to respiratory disturbance during hypoxia

Tetsuya Adachi , Hiromasa Ogawa , Shinichi Okabe , Tomomi Kitamuro , Yoshihiro Kikuchi , Shigeki Shibahara , Kunio Shirato , Wataru Hida

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 209 (2) 125 - 134 2006-06

48.

Identification of adipocyte differentiation-related regulatory element for adrenomedullin gene repression (ADRE-AR) in 3T3-L1 cells

Yin Li , Yan Zhang , Kazumichi Furuyama , Satoru Yokoyama , Kazuhisa Takeda , Shigeki Shibahara , Kazuhiro Takahashi

PEPTIDES 27 (6) 1405 - 1414 2006-06

49.

SOX10, in combination with Sp1, regulates the endothelin receptor type B gene in human melanocyte lineage cells

S Yokoyama , K Takeda , S Shibahara

FEBS JOURNAL 273 (8) 1805 - 1820 2006-04

50.

Association of susceptibility to the development of pneumonia in the older Japanese population with haem oxygenase-1 gene promoter polymorphism

H Yasuda , S Okinaga , M Yamaya , T Ohrui , M Higuchi , M Shinkawa , S Itabashi , K Nakayama , M Asada , A Kikuchi , S Shibahara , H Sasaki

JOURNAL OF MEDICAL GENETICS 43 (4) e17-e17 - 2006-04

51.

Arg452 substitution of the erythroid-specific 5-aminolaevulinate synthase, a hot spot mutation in X-linked sideroblastic anaemia, does not itself affect enzyme activity

K Furuyama , H Harigae , T Heller , BCJ Hamel , EI Minder , T Shimizu , T Kuribara , N Blijlevens , S Shibahara , S Sassa

EUROPEAN JOURNAL OF HAEMATOLOGY 76 (1) 33 - 41 2006-01

52.

Lipocalin-type prostaglandin D synthase as a melanocyte marker regulated by MITF

K Takeda , S Yokoyama , H Aburatani , T Masuda , F Han , M Yoshizawa , N Yamaki , H Yamamoto , N Eguchi , Y Urade , S Shibahara

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 339 (4) 1098 - 1106 2006-01

53.

Dynamic changes in expression of heme oxygenases in mouse heart and liver during hypoxia

F Han , K Takeda , S Yokoyama , H Ueda , Y Shinozawa , K Furuyama , S Shibahara

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 338 (1) 653 - 659 2005-12

54.

Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to cerebral malaria in Myanmar

M Takeda , M Kikuchi , R Ubalee , K Na-Bangchang , R Ruangweerayut , S Shibahara , S Imai , K Hirayama

JAPANESE JOURNAL OF INFECTIOUS DISEASES 58 (5) 268 - 271 2005-10

55.

Dynamic regulation of the human dopachrome tautomerase promoter by MITF, ER-alpha and chromatin remodelers during proliferation and senescence of human melanocytes

DJ Schwahn , NA Timchenko , S Shibahara , EE Medrano

PIGMENT CELL RESEARCH 18 (3) 203 - 213 2005-06

56.

Association of susceptibility to the development of lung adenocarcinoma with the heme oxygenase-1 gene promoter polymorphism

A Kikuchi , M Yamaya , S Suzuki , H Yasuda , H Kubo , K Nakayama , M Handa , T Sasaki , S Shibahara , K Sekizawa , H Sasaki

HUMAN GENETICS 116 (5) 354 - 360 2005-04

57.

Suppression of cytokine-induced expression of endothelin-1 by dexamethasone in human retinal pigment epithelial cells

Reiko Udono-Fujimori , Kazuhito Totsune , Osamu Murakami , Zenei Arihara , Kumi Kikuchi , Makoto Tamai , Shigeki Shibahara , Kazuhiro Takahashi

Journal of Cardiovascular Pharmacology 44 (1) S471 - S473 2004-11

58.

Urocortins as cardiovascular peptides

K Takahashi , K Totsune , O Murakami , S Shibahara

PEPTIDES 25 (10) 1723 - 1731 2004-10

59.

Melanin pigmentation in mammalian skin and its hormonal regulation

A Slominski , DJ Tobin , S Shibahara , J Wortsman

PHYSIOLOGICAL REVIEWS 84 (4) 1155 - 1228 2004-10

60.

Regulation of heme oxygenase-1 gene transcription: Recent advances and highlights from the International Conference (Uppsala, 2003) on heme oxygenase

J Alam , K Igarashi , S Immenschuh , S Shibahara , RM Tyrrell

ANTIOXIDANTS & REDOX SIGNALING 6 (5) 924 - 933 2004-10

61.

Expression of heme oxygenase-1 is repressed by interferon-gamma and induced by hypoxia in human retinal pigment epithelial cells

R Udono-Fujimori , K Takahashi , K Takeda , K Furuyama , K Kaneko , S Takahashi , M Tamai , S Shibahara

EUROPEAN JOURNAL OF BIOCHEMISTRY 271 (14) 3076 - 3084 2004-07

62.

Hypoxemia and blunted hypoxic ventilatory responses in mice lacking heme oxygenase-2 ラスト(シニア)オーサー / 責任著者

T Adachi , K Ishikawa , W Hida , H Matsumoto , T Masuda , F Date , K Ogawa , K Takeda , K Furuyama , YZ Zhang , T Kitamuro , H Ogawa , Y Maruyama , S Shibahara

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 320 (2) 514 - 522 2004-07

63.

Expression of urocortin III/stresscopin in human heart and kidney

K Takahashi , K Totsune , O Murakami , M Saruta , M Nakabayashi , T Suzuki , H Sasano , S Shibahara

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 89 (4) 1897 - 1903 2004-04

64.

Cloning and functional analysis of ascidian Mitf in vivo: insights into the origin of vertebrate pigment cells

Yajima, I , K Endo , S Sato , R Toyoda , H Wada , S Shibahara , T Numakunai , K Ikeo , T Gojobori , CR Goding , H Yamamoto

MECHANISMS OF DEVELOPMENT 120 (12) 1489 - 1504 2003-12

65.

Differential expression of adrenomedullin and resistin in 3T3-L1 adipocytes treated with tumor necrosis factor-alpha

Y Li , K Totsune , K Takeda , K Furuyama , S Shibahara , K Takahashi

EUROPEAN JOURNAL OF ENDOCRINOLOGY 149 (3) 231 - 238 2003-09

66.

Microsatellite polymorphism in heme oxygenase-1 gene promoter is associated with susceptibility to oxidant-induced apoptosis in lymphoblastoid cell lines

H Hirai , H Kubo , M Yamaya , K Nakayama , M Numasaki , S Kobayashi , S Suzuki , S Shibahara , H Sasaki

BLOOD 102 (5) 1619 - 1621 2003-09

67.

The heme oxygenase dilemma in cellular homeostasis: New insights for the feedback regulation of heme catabolism

S Shibahara

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 200 (4) 167 - 186 2003-08

68.

Neonatal hyperbilirubinemia in Japanese neonates: Analysis of the heme oxygenase-1 gene and fetal hemoglobin composition in cord blood

M Kanai , K Akaba , A Sasaki , M Sato , T Harano , S Shibahara , H Kurachi , T Yoshida , K Hayasaka

PEDIATRIC RESEARCH 54 (2) 165 - 171 2003-08

69.

Suppression of cytokine-induced expression of adrenomedullin and endothelin-1 by dexamethasone in T98G human glioblastoma cells

K Takahashi , R Udono-Fujimori , K Totsune , O Murakami , S Shibahara

PEPTIDES 24 (7) 1053 - 1062 2003-07

70.

Germ cell-specific expression of microphthalmia-associated transcription factor mRNA in mouse testis ラスト(シニア)オーサー / 責任著者

H Saito , K Takeda , K Yasumoto , H Ohtani , K Watanabe , K Takahashi , A Fukuzaki , Y Arai , H Yamamoto , S Shibahara

JOURNAL OF BIOCHEMISTRY 134 (1) 143 - 150 2003-07

71.

Adrenomedullin in the eye

R Udono-Fujimori , T Udono , K Totsune , M Tamai , S Shibahara , K Takahashi

REGULATORY PEPTIDES 112 (1-3) 95 - 101 2003-04

72.

HLF/HIF-2 alpha is a key factor in retinopathy of prematurity in association with erythropoietin

M Morita , O Ohneda , T Yamashita , S Takahashi , N Suzuki , O Nakajima , S Kawauchi , M Ema , S Shibahara , T Udono , K Tomita , M Tamai , K Sogawa , M Yamamoto , Y Fujii-Kuriyama

EMBO JOURNAL 22 (5) 1134 - 1146 2003-03

73.

Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells

T Kitamuro , K Takahashi , K Ogawa , R Udono-Fujimori , K Takeda , K Furuyama , M Nakayama , JY Sun , H Fujita , W Hida , T Hattori , K Shirato , K Igarashi , S Shibahara

JOURNAL OF BIOLOGICAL CHEMISTRY 278 (11) 9125 - 9133 2003-03

74.

Expression of urotensin II and its receptor in adrenal tumors and stimulation of proliferation of cultured tumor cells by urotensin II

K Takahashi , K Totsune , O Murakami , Z Arihara , T Noshiro , Y Hayashi , S Shibahara

PEPTIDES 24 (2) 301 - 306 2003-02

75.

Increased dopamine and its metabolites in SH-SY5Y neuroblastoma cells that express tyrosinase.

Hasegawa Takafumi , Matsuzaki Michiko , Takeda Atsushi , Kikuchi Akio , Furukawa Katsutoshi , Shibahara Shigeki , Itoyama Yasuto

J Neurochem 87 (2) 470 - 475 2003

76.

OTX2 regulates expression of DOPAchrome tautomerase in human retinal pigment epithelium

K Takeda , S Yokoyama , K Yasumoto , H Saito , T Udono , K Takahashi , S Shibahara

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 300 (4) 908 - 914 2003-01

77.

Altered expression of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukaemia

O Sasaki , K Meguro , Y Tohmiya , T Funato , S Shibahara , T Sasaki

BRITISH JOURNAL OF HAEMATOLOGY 119 (4) 940 - 948 2002-12

78.

Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene

JY Sun , H Hoshino , K Takaku , O Nakajima , A Muto , H Suzuki , S Tashiro , S Takahashi , S Shibahara , J Alam , MM Taketo , M Yamamoto , K Igarashi

EMBO JOURNAL 21 (19) 5216 - 5224 2002-10

79.

Elevated immunoreactive-adrenomedullin levels in the aqueous humor of patients with uveitis and vitreoretinal disorders

Tetsuo Udono , Kazuhiro Takahashi , Toshiaki Abe , Shigeki Shibahara , Makoto Tamai

Peptides 23 (10) 1865 - 1868 2002-10-01

80.

Heme degradation and human disease: Diversity is the soul of life 筆頭著者 / 責任著者

S Shibahara , T Kitamuro , K Takahashi

ANTIOXIDANTS & REDOX SIGNALING 4 (4) 593 - 602 2002-08

81.

Three vasoactive peptides, endothelin-1, adrenomedullin and urotensin-II, in human tumour cell lines of different origin: Expression and effects on proliferation ラスト(シニア)オーサー

Kazuhiro Takahashi , Kazuhito Totsune , Tomomi Kitamuro , Masahiko Sone , Osamu Murakami , Shigeki Shibahara

Clinical Science 103 (48) 35S-38S - 2002-08

82.

Melanocyte-specific microphthalmia-associated transcription factor isoform activates its own gene promoter through physical interaction with lymphoid-enhancing factor 1 ラスト(シニア)オーサー / 責任著者

H Saito , K Yasumoto , K Takeda , K Takahashi , A Fukuzaki , S Orikasa , S Shibahara

JOURNAL OF BIOLOGICAL CHEMISTRY 277 (32) 28787 - 28794 2002-08

83.

Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling ラスト(シニア)オーサー / 責任著者

Ken-ichi Yasumoto , Kazuhisa Takeda , Hideo Saito , Ken-ichi Watanabe , Kazuhiro Takahashi , Shigeki Shibahara

EMBO Journal 21 (11) 2703 - 2714 2002-06-03

84.

Expression of prolactin-releasing peptide and its receptor in the human adrenal glands and tumor tissues of adrenocortical tumors, pheochromocytomas and neuroblastomas ラスト(シニア)オーサー

K Takahashi , K Totsune , O Murakami , M Sone , T Noshiro , Y Hayashi , H Sasano , S Shibahara

PEPTIDES 23 (6) 1135 - 1140 2002-06

85.

Identification of a distal enhancer for the melanocyte-specific promoter of the MITF gene ラスト(シニア)オーサー / 責任著者

KI Watanabe , K Takeda , KI Yasumoto , T Udono , H Saito , K Ikeda , T Takasaka , K Takahashi , T Kobayashi , M Tachibana , S Shibahara

PIGMENT CELL RESEARCH 15 (3) 201 - 211 2002-06

86.

Nucleotide alteration of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukemia

O Sasaki , K Meguro , Y Tohmiya , T Funato , S Shibahara , T Sasaki

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 196 (3) 193 - 201 2002-03

87.

Mitf-D, a newly identified isoform, expressed in the retinal pigment epithelium and monocyte-lineage cells affected by Mitf mutations ラスト(シニア)オーサー / 責任著者

K Takeda , K Yasumoto , N Kawaguchi , T Udono , K Watanabe , H Saito , K Takahashi , M Noda , S Shibahara

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1574 (1) 15 - 23 2002-02

88.

Microphthalmia-associated transcription factor (MITF): Multiplicity in structure, function, and regulation

S Shibahara , K Takeda , K Yasumoto , T Udono , K Watanabe , H Saito , K Takahashi

JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS 6 (1) 99 - 104 2001-11

89.

Differential expression of adrenomedullin and its receptor component, receptor activity modifying protein (RAMP) 2 during hypoxia in cultured human neuroblastoma cells ラスト(シニア)オーサー

T Kitamuro , K Takahashi , K Totsune , M Nakayama , O Murakami , W Hida , K Shirato , S Shibahara

PEPTIDES 22 (11) 1795 - 1801 2001-11

90.

Increased expression of heme oxygenase-1 and bilirubin accumulation in foam cells of rabbit atherosclerotic lesions ラスト(シニア)オーサー

M Nakayama , K Takahashi , T Komaru , M Fukuchi , H Shioiri , K Sato , T Kitamuro , K Shirato , T Yamaguchi , M Suematsu , S Shibahara

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 21 (8) 1373 - 1377 2001-08

91.

Expression of urotensin II and urotensin II receptor mRNAs in various human tumor cell lines and secretion of urotensin II-like immunoreactivity by SW-13 adrenocortical carcinoma cells ラスト(シニア)オーサー

K Takahashi , K Totsune , O Murakami , S Shibahara

PEPTIDES 22 (7) 1175 - 1179 2001-07

92.

Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1

K Ogawa , J Sun , S Taketani , O Nakajima , C Nishitani , S Sassa , N Hayashi , M Yamamoto , S Shibahara , H Fujita , K Igarashi

EMBO JOURNAL 20 (11) 2835 - 2843 2001-06

93.

Expression of tyrosinase-related protein 2/DOPAchrome tautomerase in the retinoblastoma ラスト(シニア)オーサー / 責任著者

T Udono , K Takahashi , K Yasumoto , M Yoshizawa , K Takeda , T Abe , M Tamai , S Shibahara

EXPERIMENTAL EYE RESEARCH 72 (3) 225 - 234 2001-03

94.

Expression of melanin-concentrating hormone receptor messenger ribonucleic acid in tumor tissues of pheochromocytoma, ganglioneuroblastoma, and neuroblastoma ラスト(シニア)オーサー

K Takahashi , K Totsune , O Murakami , N Sone , F Satoh , T Kitamuro , T Noshiro , Y Hayashi , H Sasano , S Shibahara

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 86 (1) 369 - 374 2001-01

95.

Induction of adrenomedullin by hypoxia in cultured retinal pigment epithelial cells ラスト(シニア)オーサー

T. Udono , K. Takahashi , M. Nakayama , A. Yoshinoya , K. Totsune , O. Murakami , Y. K. Durlu , M. Tamai , S. Shibahara

Investigative Ophthalmology and Visual Science 42 (5) 1080 - 1086 2001

96.

Urea and hypertonicity increase expression of heme oxygenase-1 in murine renal medullary cells.

Tian W , Bonkovsky H L , Shibahara S , Cohen D M

Am J Physiol Renal Physiol 281 (5) F983-91 - 2001

97.

Expression of the Sox10 gene during mouse inner ear development ラスト(シニア)オーサー / 責任著者

K Watanabe , K Takeda , Y Katori , K Ikeda , T Oshima , K Yasumoto , H Saito , T Takasaka , S Shibahara

MOLECULAR BRAIN RESEARCH 84 (1-2) 141 - 145 2000-12

98.

Induction of adrenomedullin during hypoxia in cultured human glioblastoma cells ラスト(シニア)オーサー

T Kitamuro , K Takahashi , M Nakayama , O Murakami , W Hida , K Shirato , S Shibahara

JOURNAL OF NEUROCHEMISTRY 75 (5) 1826 - 1833 2000-11

99.

Regional distribution of immunoreactive prolactin-releasing peptide in the human brain ラスト(シニア)オーサー

K Takahashi , A Yoshinoya , Z Arihara , O Murakami , K Totsune , M Sone , H Sasano , S Shibahara

PEPTIDES 21 (10) 1551 - 1555 2000-10

100.

Identification of a composite enhancer of the human tyrosinase-related protein 2/DOPAchrome tautomerase gene ラスト(シニア)オーサー / 責任著者

S Amae , K Yasumoto , K Takeda , T Udono , K Takahashi , S Shibahara

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1492 (2-3) 505 - 508 2000-07

101.

Transcriptional control of adrenomedullin induction by phorbol ester in human monocytic leukemia cells ラスト(シニア)オーサー

M Nakayama , K Takahashi , T Kitamuro , O Murakami , K Shirato , S Shibahara

EUROPEAN JOURNAL OF BIOCHEMISTRY 267 (12) 3559 - 3566 2000-06

102.

Induction of melanocyte-specific microphthalmia-associated transcription factor by Wnt-3a ラスト(シニア)オーサー / 責任著者

K Takeda , K Yasumoto , R Takada , S Takada , K Watanabe , T Udono , H Saito , K Takahashi , S Shibahara

JOURNAL OF BIOLOGICAL CHEMISTRY 275 (19) 14013 - 14016 2000-05

103.

Repression of heme oxygenase-1 by hypoxia in vascular endothelial cells ラスト(シニア)オーサー / 責任著者

M Nakayama , K Takahashi , T Kitamuro , K Yasumoto , D Katayose , K Shirato , Y Fujii-Kuriyama , S Shibahara

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 271 (3) 665 - 671 2000-05

104.

Increased expression of adrenomedullin mRNA in the tissues of intraocular and orbital tumors

T Udono , K Totsune , K Takahashi , T Abe , M Sato , S Shibahara , M Tamai

AMERICAN JOURNAL OF OPHTHALMOLOGY 129 (4) 555 - 556 2000-04

105.

Structural organization of the human microphthalmia-associated transcription factor gene containing four alternative promoters ラスト(シニア)オーサー / 責任著者

T Udono , K Yasumoto , K Takeda , S Amae , K Watanabe , H Saito , N Fuse , M Tachibana , K Takahashi , M Tamai , S Shibahara

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1491 (1-3) 205 - 219 2000-04

106.

Production and secretion of two vasoactive peptides, adrenomedullin and endothelin-1, by cultured human adrenocortical carcinoma cells ラスト(シニア)オーサー

Kazuhiro Takahashi , Ayako Yoshinoya , Osamu Murakami , Kazuhito Totsune , Shigeki Shibahara

Peptides 21 (2) 251 - 256 2000-02

107.

Secretion of endothelin-1 and adrenomedullin by SW-13 human adrenocortical carcinoma cells ラスト(シニア)オーサー

K Takahashi , A Yoshinoya , O Murakami , K Totsune , S Shibahara

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 36 (5 Suppl 1) S393 - S394 2000

108.

Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema

Norihiro Yamada , Mutsuo Yamaya , Shoji Okinaga , Katsutoshi Nakayama , Kiyohisa Sekizawa , Shigeki Shibahara , Hidetada Sasaki

American Journal of Human Genetics 66 (1) 187 - 195 2000

109.

Increased secretion of adrenomedullin from cultured human astrocytes by cytokines ラスト(シニア)オーサー

K Takahashi , M Nakayama , K Totsune , O Murakami , M Sone , T Kitamuro , A Yoshinoya , S Shibahara

JOURNAL OF NEUROCHEMISTRY 74 (1) 99 - 103 2000-01

110.

Regulation of pigment cell-specific gene expression by MITF

Shigeki Shibahara , Ken-Ichi Yasumoto , Shintaro Amae , Tetsuo Udono , Ken-Ichi Watanabe , Hideo Saito , Kazuhisa Takeda

Pigment Cell Research 13 (8) 98 - 102 2000

111.

Expression of endothelin-1 and endothelin receptors in cultured human glioblastoma cells ラスト(シニア)オーサー

M Sone , K Takahashi , K Totsune , O Murakami , Z Arihara , F Satoh , T Mouri , S Shibahara

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 36 (5 Suppl 1) S390 - S392 2000

112.

Elevated adrenomedullin in the vitreous of patients with proliferative vitreoretinopathy

T Udono , K Takahashi , S Takano , S Shibahara , M Tamai

AMERICAN JOURNAL OF OPHTHALMOLOGY 128 (6) 765 - 767 1999-12

113.

Molecular cloning of cDNA encoding a novel microphthalmia-associated transcription factor isoform with a distinct amino-terminus ラスト(シニア)オーサー / 責任著者

N Fuse , K Yasumoto , K Takeda , S Amae , M Yoshizawa , T Udono , K Takahashi , M Tamai , Y Tomita , M Tachibana , S Shibahara

JOURNAL OF BIOCHEMISTRY 126 (6) 1043 - 1051 1999-12

114.

Positive and negative regulation of the human heme oxygenase-1 gene expression in cultured cells

S Takahashi , Y Takahashi , K Ito , T Nagano , S Shibahara , T Miura

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1447 (2-3) 231 - 235 1999-10

115.

Production and secretion of adrenomedullin in cultured human alveolar macrophages ラスト(シニア)オーサー

M Nakayama , K Takahashi , O Murakami , M Yanai , H Sasaki , K Shirato , S Shibahara

PEPTIDES 20 (9) 1123 - 1125 1999-09

116.

An L1 element intronic insertion in the black-eyed white (Mitf(mi-bw)) gene: the loss of a single Mitf isoform responsible for the pigmentary defect and inner ear deafness

Yajima, I , S Sato , T Kimura , K Yasumoto , S Shibahara , CR Goding , H Yamamoto

HUMAN MOLECULAR GENETICS 8 (8) 1431 - 1441 1999-08

117.

Adrenomedullin in monocytes and macrophages: possible involvement of macrophage-derived adrenomedullin in atherogenesis

M Nakayama , K Takahashi , O Murakami , H Murakami , H Sasano , K Shirato , S Shibahara

CLINICAL SCIENCE 97 (2) 247 - 251 1999-08

118.

Induction of adrenomedullin by hypoxia in cultured human coronary artery endothelial cells ラスト(シニア)オーサー

Masaharu Nakayama , Kazuhiro Takahashi , Osamu Murakami , Kunio Shirato , Shigeki Shibahara

Peptides 20 (6) 769 - 772 1999-08

119.

Induction of heme oxygenase-1 as a response in sensing the signals evoked by distinct nitric oxide donors ラスト(シニア)オーサー / 責任著者

E Hara , K Takahashi , K Takeda , M Nakayama , M Yoshizawa , H Fujita , K Shirato , S Shibahara

BIOCHEMICAL PHARMACOLOGY 58 (2) 227 - 236 1999-07

120.

Suppression of heme oxygenase-1 mRNA expression by interferon-gamma in human glioblastoma cells ラスト(シニア)オーサー

K Takahashi , M Nakayama , K Takeda , H Fujita , S Shibahara

JOURNAL OF NEUROCHEMISTRY 72 (6) 2356 - 2361 1999-06

121.

Isoform multiplicity of microphthalmia-associated transcription factor

K Yasumoto , S Shibahara

SEIKAGAKU 71 (1) 61 - 64 1999-01

122.

Induction of haem oxygenase-1 by nitric oxide and ischaemia in experimental solid tumours and implications for tumour growth

K. Doi , T. Akaike , S. Fujii , S. Tanaka , N. Ikebe , T. Beppu , S. Shibahara , M. Ogawa , H. Maeda

British Journal of Cancer 80 (12) 1945 - 1954 1999

123.

Implications of isoform multiplicity of microphthalmia-associated transcription factor in the pathogenesis of auditory-pigmentary syndromes 筆頭著者 / 責任著者

Shigeki Shibahara , Ken-Ichi Yasumoto , Shintaro Amae , Nobuo Fuse , Tetsuo Udono , Kazuhiro Takahashi

Journal of Investigative Dermatology Symposium Proceedings 4 (2) 101 - 104 1999

124.

A big gene linked to small eyes encodes multiple Mitf isoforms: Many promoters make light work ラスト(シニア)オーサー / 責任著者

K Yasumoto , S Amae , T Udono , N Fuse , K Takeda , S Shibahara

PIGMENT CELL RESEARCH 11 (6) 329 - 336 1998-12

125.

Production and secretion of neuropeptides by nervous system tumors (vol 11, pg 237, 1998) ラスト(シニア)オーサー

K Takahashi , M Nakayama , S Shibahara

CANCER JOURNAL 11 (6) 293 - 293 1998-11

126.

Role of neurofibromin in modulation of expression of the tyrosinase-related protein 2 gene ラスト(シニア)オーサー / 責任著者

H Suzuki , K Takahashi , K Yasumoto , S Amae , M Yoshizawa , N Fuse , S Shibahara

JOURNAL OF BIOCHEMISTRY 124 (5) 992 - 998 1998-11

127.

Identification of a novel isoform of microphthalmia-associated transcription factor that is enriched in retinal pigment epithelium ラスト(シニア)オーサー / 責任著者

S Amae , N Fuse , K Yasumoto , S Sato , Yajima, I , H Yamamoto , T Udono , YK Durlu , M Tamai , K Takahashi , S Shibahara

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 247 (3) 710 - 715 1998-06

128.

Production and secretion of neuropeptides by nervous system tumors (Canc J) ラスト(シニア)オーサー

K Takahashi , M Nakayama , S Shibahara

Canc J 11 237 - 241 1998-04

129.

Induction of adrenomedullin by hypoxia and cobalt chloride in human colorectal carcinoma cells ラスト(シニア)オーサー

M Nakayama , K Takahashi , O Murakami , K Shirato , S Shibahara

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 243 (2) 514 - 517 1998-02

130.

Retinal pigment epithelial cell-based gene therapy against hemoglobin toxicity. ラスト(シニア)オーサー

Abraham N G , Da Silva J L , Dunn M W , Kigasawa K , Shibahara S

Int J Mol Med 1 (4) 657 - 663 1998

131.

Production and secretion of two vasoactive peptides, endothelin-1 and adrenomedullin, by a colorectal adenocarcinoma cell line, DLD-1

Masaharu Nakayama , Kazuhiro Takahashi , Eishi Hara , Osamu Murakami , Kazuhito Totsune , Masahiko Sone , Fumitoshi Satoh , Shigeki Shibahara

Journal of Cardiovascular Pharmacology 31 (1) S534 - S536 1998

132.

Production and secretion of endothelin-1 by cultured choroid plexus carcinoma cells

K Takahashi , E Hara , O Murakami , K Totsune , M Sone , F Satoh , T Kumabe , T Tominaga , T Kayama , T Yoshimoto , S Shibahara

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 31 S367 - S369 1998

133.

Molecular cloning of cDNA encoding a human TFEC isoform, a newly identified transcriptional regulator ラスト(シニア)オーサー / 責任著者

Ken-Ichi Yasumoto , Shigeki Shibahara

Biochimica et Biophysica Acta - Gene Structure and Expression 1353 (1) 23 - 31 1997-07-17

134.

Microsatellite polymorphism in the human heme oxygenase-1 gene promoter and its application in association studies with Alzheimer and Parkinson disease ラスト(シニア)オーサー

T Kimpara , A Takeda , K Watanabe , Y Itoyama , S Ikawa , M Watanabe , H Arai , H Sasaki , S Higuchi , N Okita , S Takase , H Saito , K Takahashi , S Shibahara

HUMAN GENETICS 100 (1) 145 - 147 1997-07

135.

Possible implications of the induction of human heme oxygenase-1 by nitric oxide donors ラスト(シニア)オーサー / 責任著者

K Takahashi , E Hara , K Ogawa , D Kimura , H Fujita , S Shibahara

JOURNAL OF BIOCHEMISTRY 121 (6) 1162 - 1168 1997-06

136.

Diminished heme oxygenase-1 mRNA expression in RPE cells from diabetic donors as quantitated by competitive RT/PCR ラスト(シニア)オーサー

JL daSilva , RA Stoltz , MW Dunn , NG Abraham , S Shibahara

CURRENT EYE RESEARCH 16 (4) 380 - 386 1997-04

137.

Production and secretion of adrenomedullin by cultured choroid plexus carcinoma cells ラスト(シニア)オーサー

K Takahashi , F Satoh , E Hara , O Murakami , T Kumabe , T Tominaga , T Kayama , T Yoshimoto , S Shibahara

JOURNAL OF NEUROCHEMISTRY 68 (2) 726 - 731 1997-02

138.

Functional analysis of microphthalmia-associated transcription factor in pigment cell-specific transcription of the human tyrosinase family genes ラスト(シニア)オーサー / 責任著者

K Yasumoto , K Yokoyama , K Takahashi , Y Tomita , S Shibahara

JOURNAL OF BIOLOGICAL CHEMISTRY 272 (1) 503 - 509 1997-01

139.

Production and secretion of adrenomedullin from glial cell tumors and its effects on cAMP production ラスト(シニア)オーサー

K Takahashi , F Satoh , E Hara , M Sone , O Murakami , T Kayama , T Yoshimoto , S Shibahara

PEPTIDES 18 (8) 1117 - 1124 1997

140.

Expression of adrenomedullin mRNA in the human brain and pituitary ラスト(シニア)オーサー

Kazuhiro Takahashi , Fumitoshi Satoh , Masahiko Sone , Osamu Murakami , Hironobu Sasano , Toraichi Mouri , Shigeki Shibahara

Peptides 18 (7) 1051 - 1053 1997

141.

Detection of mouse tyrosinase with a monoclonal antibody MAT-1 against human tyrosinase

S Suzuki , H Takimoto , S Masui , T Kato , K Shibata , Y Tomita , S Shibahara , H Nakano

PIGMENT CELL RESEARCH 9 (6) 298 - 303 1996-12

142.

Differential tissue-specific expression of neurofibromin isoform mRNAs in rat ラスト(シニア)オーサー / 責任著者

H Suzuki , K Takahashi , K Yasumoto , N Fuse , S Shibahara

JOURNAL OF BIOCHEMISTRY 120 (5) 1048 - 1054 1996-11

143.

Expression of heme oxygenase isozyme mRNAs in the human brain and induction of heme oxygenase-1 by nitric oxide donors ラスト(シニア)オーサー

K Takahashi , E Hara , H Suzuki , H Sasano , S Shibahara

JOURNAL OF NEUROCHEMISTRY 67 (2) 482 - 489 1996-08

144.

Expression of heme oxygenase and inducible nitric oxide synthase mRNA in human brain tumors ラスト(シニア)オーサー / 責任著者

E Hara , K Takahashi , T Tominaga , T Kumabe , T Kayama , H Suzuki , H Fujita , T Yoshimoto , K Shirato , S Shibahara

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 224 (1) 153 - 158 1996-07

145.

Regulation of human heme oxygenase-1 gene expression under thermal stress ラスト(シニア)オーサー

S Okinaga , K Takahashi , K Takeda , M Yoshizawa , H Fujita , H Sasaki , S Shibahara

BLOOD 87 (12) 5074 - 5084 1996-06

146.

Regional difference in induction of heme oxygenase-1 protein following rat transient forebrain ischemia

A Takeda , T Kimpara , H Onodera , Y Itoyama , S Shibahara , K Kogure

NEUROSCIENCE LETTERS 205 (3) 169 - 172 1996-03

147.

cDNA cloning of a novel protein containing two zinc-finger domains that may function as a transcription factor for the human heme-oxygenase-1 gene ラスト(シニア)オーサー / 責任著者

Y Muraosa , K Takahashi , M Yoshizawa , S Shibahara

EUROPEAN JOURNAL OF BIOCHEMISTRY 235 (3) 471 - 479 1996-02

148.

Identification of a melanocyte-type promoter of the microphthalmia-associated transcription factor gene ラスト(シニア)オーサー / 責任著者

N Fuse , K Yasumoto , H Suzuki , K Takahashi , S Shibahara

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 219 (3) 702 - 707 1996-02

149.

Transcriptional control of the human heme oxygenase-1 gene by stress 筆頭著者 / 責任著者

S Shibahara , K Takeda , S Okinaga , M Yoshizawa , K Takahashi , H Fujita

MOLECULAR BIOLOGY OF HEMATOPOIESIS 5 53 439 - 444 1996

150.

MAT-1, A MONOCLONAL-ANTIBODY THAT SPECIFICALLY RECOGNIZES HUMAN TYROSINASE

H TAKIMOTO , S SUZUKI , S MASUI , K SHIBATA , Y TOMITA , S SHIBAHARA , H NAKANO

JOURNAL OF INVESTIGATIVE DERMATOLOGY 105 (6) 764 - 768 1995-12

151.

TRANSCRIPTIONAL ACTIVATION OF THE MELANOCYTE-SPECIFIC GENES BY THE HUMAN HOMOLOG OF THE MOUSE MICROPHTHALMIA PROTEIN ラスト(シニア)オーサー / 責任著者

K YASUMOTO , H MAHALINGAM , H SUZUKI , M YOSHIZAWA , K YOKOYAMA , S SHIBAHARA

JOURNAL OF BIOCHEMISTRY 118 (5) 874 - 881 1995-11

152.

INDUCTION OF HEPARIN-BINDING GROWTH-ASSOCIATED MOLECULE EXPRESSION IN REACTIVE ASTROCYTES FOLLOWING HIPPOCAMPAL NEURONAL INJURY ラスト(シニア)オーサー

A TAKEDA , H ONODERA , A SUGIMOTO , Y ITOYAMA , K KOGURE , H RAUVALA , S SHIBAHARA

NEUROSCIENCE 68 (1) 57 - 64 1995-09

153.

TRANSFECTION OF THE HUMAN HEME OXYGENASE GENE INTO RABBIT CORONARY MICROVESSEL ENDOTHELIAL-CELLS - PROTECTIVE EFFECT AGAINST HEME AND HEMOGLOBIN TOXICITY

NG ABRAHAM , Y LAVROVSKY , ML SCHWARTZMAN , RA STOLTZ , RD LEVERE , ME GERRITSEN , S SHIBAHARA , A KAPPAS

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 92 (15) 6798 - 6802 1995-07

154.

MELANIN-CONCENTRATING HORMONE IN HUMAN AND RAT ラスト(シニア)オーサー

K TAKAHASHI , H SUZUKI , K TOTSUNE , O MURAKAMI , F SATOH , M SONE , H SASANO , T MOURI , S SHIBAHARA

NEUROENDOCRINOLOGY 61 (5) 493 - 498 1995-05

155.

REDUCED EXPRESSION OF NEUROFIBROMIN IN THE SOFT-TISSUE TUMORS OBTAINED FROM PATIENTS WITH NEUROFIBROMATOSIS TYPE-1 ラスト(シニア)オーサー / 責任著者

K TAKAHASHI , H SUZUKI , M HATORI , Y ABE , S KOKUBUN , M SAKURAI , S SHIBAHARA

CLINICAL SCIENCE 88 (5) 581 - 585 1995-05

156.

EVIDENCE FOR THE PRESENCE OF 2 AMINO-TERMINAL ISOFORMS OF NEUROFIBROMIN, A GENE-PRODUCT RESPONSIBLE FOR NEUROFIBROMATOSIS TYPE-1 ラスト(シニア)オーサー / 責任著者

H SUZUKI , K TAKAHASHI , S SHIBAHARA

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 175 (4) 225 - 233 1995-04

157.

HEME OXYGENASE-2 - PROPERTIES OF THE HEME COMPLEX OF THE PURIFIED TRYPTIC FRAGMENT OF RECOMBINANT HUMAN HEME OXYGENASE-2

K ISHIKAWA , N TAKEUCHI , S TAKAHASHI , KM MATERA , M SATO , S SHIBAHARA , DL ROUSSEAU , M IKEDASAITO , T YOSHIDA

JOURNAL OF BIOLOGICAL CHEMISTRY 270 (11) 6345 - 6350 1995-03

158.

DIFFERENTIAL CONTROL OF THE METAL-MEDIATED ACTIVATION OF THE HUMAN HEME OXYGENASE-1 AND METALLOTHIONEIN IIA GENES ラスト(シニア)オーサー / 責任著者

K TAKEDA , H FUJITA , S SHIBAHARA

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 207 (1) 160 - 167 1995-02

159.

INCREASED EXPRESSION OF HEME OXYGENASE MESSENGER-RNA IN RAT-BRAIN FOLLOWING TRANSIENT FOREBRAIN ISCHEMIA ラスト(シニア)オーサー

A TAKEDA , H ONODERA , A SUGIMOTO , Y ITOYAMA , K KOGURE , S SHIBAHARA

BRAIN RESEARCH 666 (1) 120 - 124 1994-12

160.

ACTIVATION OF THE TYROSINASE GENE PROMOTER BY NEUROFIBROMIN ラスト(シニア)オーサー / 責任著者

H SUZUKI , K TAKAHASHI , K YASUMOTO , S SHIBAHARA

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 205 (3) 1984 - 1991 1994-12

161.

Cloning of the human DOPAchrome tautomerase/tyrosinase-related protein 2 gene and identification of two regulatory regions required for its pigment cell-specific expression ラスト(シニア)オーサー / 責任著者

Kouji Yokoyama , Ken-Ichi Yasumoto , Hiroyuki Suzuki , Shigeki Shibahara

Journal of Biological Chemistry 269 (43) 27080 - 27087 1994-10-28

162.

IDENTIFICATION OF A CIS-ACTING ELEMENT THAT IS RESPONSIBLE FOR CADMIUM-MEDIATED INDUCTION OF THE HUMAN HEME OXYGENASE GENE ラスト(シニア)オーサー / 責任著者

K TAKEDA , S ISHIZAWA , M SATO , T YOSHIDA , S SHIBAHARA

JOURNAL OF BIOLOGICAL CHEMISTRY 269 (36) 22858 - 22867 1994-09

163.

MAPPING OF THE HUMAN GENE FOR INDUCIBLE HEME OXYGENASE TO CHROMOSOME-22Q12 ラスト(シニア)オーサー

A KUWANO , H IKEDA , K TAKEDA , H NAKAI , KONDO, I , S SHIBAHARA

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 172 (4) 389 - 392 1994-04

164.

MOLECULAR-CLONING AND FUNCTIONAL-ANALYSIS OF A CDNA CODING FOR HUMAN DOPACHROME TAUTOMERASE/TYROSINASE-RELATED PROTEIN-2 ラスト(シニア)オーサー / 責任著者

K YOKOYAMA , H SUZUKI , KI YASUMOTO , Y TOMITA , S SHIBAHARA

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1217 (3) 317 - 321 1994-04

165.

Structure and function of human histamine N-methyltransferase: Critical enzyme in histamine metabolism in airway

K. Yamauchi , K. Sekizawa , H. Suzuki , H. Nakazawa , Y. Ohkawara , D. Katayose , H. Ohtsu , G. Tamura , S. Shibahara , M. Takemura , K. Maeyama , T. Watanabe , H. Sasaki , K. Shirato , T. Takishima

American Journal of Physiology - Lung Cellular and Molecular Physiology 267 (3) L342 - L349 1994

166.

Multiple transcripts of the neurofibromatosis type I gene in human brain and in brain tumours ラスト(シニア)オーサー / 責任著者

K. Takahashi , H. Suzuki , T. Kayama , Y. Suzuki , T. Yoshimoto , H. Sasano , S. Shibahara

Clinical Science 87 (5) 481 - 485 1994

167.

Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene ラスト(シニア)オーサー / 責任著者

Ken-Ichi Yasumoto , Kouji Yokoyama , Koushi Shibata , Yasushi Tomita , Shigeki Shibahara

Molecular and Cellular Biology 14 (12) 8058 - 8070 1994

168.

COEXPRESSION OF ERYTHROPOIETIN AND HEME OXYGENASE GENES IN HEP3B CELLS

JD LUTTON , MO GRIFFIN , M NISHIMURA , RD LEVERE , A KAPPAS , NG ABRAHAM , S SHIBAHARA

HEPATOLOGY 17 (5) 861 - 868 1993-05

169.

ELEVATED LEVELS OF HEME OXYGENASE-1 ACTIVITY AND MESSENGER-RNA IN PERIPHERAL-BLOOD ADHERENT CELLS OF ACQUIRED-IMMUNODEFICIENCY-SYNDROME PATIENTS

RD LEVERE , R STAUDINGER , G LOEWY , A KAPPAS , S SHIBAHARA , NG ABRAHAM

AMERICAN JOURNAL OF HEMATOLOGY 43 (1) 19 - 23 1993-05

170.

SEPARATE REGULATION OF HEME OXYGENASE AND HEAT-SHOCK PROTEIN-70 MESSENGER-RNA EXPRESSION IN THE RAT-HEART BY HEMODYNAMIC STRESS ラスト(シニア)オーサー / 責任著者

D KATAYOSE , S ISOYAMA , H FUJITA , S SHIBAHARA

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 191 (2) 587 - 594 1993-03

171.

IDENTIFICATION OF A NUCLEAR-PROTEIN THAT CONSTITUTIVELY RECOGNIZES THE SEQUENCE CONTAINING A HEAT-SHOCK ELEMENT - ITS BINDING-PROPERTIES AND POSSIBLE FUNCTION MODULATING HEAT-SHOCK INDUCTION OF THE RAT HEME OXYGENASE GENE ラスト(シニア)オーサー / 責任著者

S OKINAGA , S SHIBAHARA

EUROPEAN JOURNAL OF BIOCHEMISTRY 212 (1) 167 - 175 1993-02

172.

Molecular biological aspects of human L-histidine decarboxy lase.

Yamauchi, K , Mamune-Sato, R , Tanno, Y , Ohtsu, H , Takishima, T , Shibahara, S , Maeyama, K , Watanabe, T

Advances in Biosciences 89 177 - 196 1993

173.

Identification of a cis-regulatory element and putative trans-acting factors responsible for 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated induction of heme oxygenase expression in myelomonocytic cell lines ラスト(シニア)オーサー / 責任著者

Y. Muraosa , S. Shibahara

Molecular and Cellular Biology 13 (12) 7881 - 7891 1993

174.

Functional analysis of the tyrosinase gene and brown-locus protein gene promoters

Shigeki Shibahara

Journal of Investigative Dermatology 100 (2) S146 - S149 1993

175.

Functional analysis of cDNAs for two types of human heme oxygenase and evidence for their separate regulation 筆頭著者 / 責任著者

Shigeki Shibahara , Miki Yoshizawa , Hiroyuki Suzuki , Kazuhisa Takeda , Kuniaki Meguro , Kazuyasu Endo

Journal of Biochemistry 113 (2) 214 - 218 1993

176.

Increased expression of PDGF A- and B-chain genes in rat lungs with hypoxic pulmonary hypertension

D. Katayose , M. Ohe , K. Yamauchi , M. Ogata , K. Shirato , H. Fujita , S. Shibahara , T. Takishima

American Journal of Physiology - Lung Cellular and Molecular Physiology 264 (2) L100 - L106 1993

177.

Coordinated expression of messenger RNAs for nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 in the rat hippocampus following transient forebrain ischemia ラスト(シニア)オーサー

A. Takeda , H. Onodera , A. Sugimoto , K. Kogure , M. Obinata , S. Shibahara

Neuroscience 55 (1) 23 - 31 1993

178.

FUNCTIONAL-ANALYSIS OF ALTERNATIVELY SPLICED TRANSCRIPTS OF THE HUMAN HISTIDINE-DECARBOXYLASE GENE AND ITS EXPRESSION IN HUMAN TISSUES AND BASOPHILIC LEUKEMIA-CELLS

R MAMUNESATO , K YAMAUCHI , Y TANNO , Y OHKAWARA , H OHTSU , D KATAYOSE , K MAEYAMA , T WATANABE , S SHIBAHARA , T TAKISHIMA

EUROPEAN JOURNAL OF BIOCHEMISTRY 209 (2) 533 - 539 1992-10

179.

IDENTIFICATION OF A CIS-ACTING ELEMENT THAT ENHANCES THE PIGMENT CELL-SPECIFIC EXPRESSION OF THE HUMAN TYROSINASE GENE ラスト(シニア)オーサー / 責任著者

K SHIBATA , Y MURAOSA , Y TOMITA , H TAGAMI , S SHIBAHARA

JOURNAL OF BIOLOGICAL CHEMISTRY 267 (29) 20584 - 20588 1992-10

180.

MOLECULAR-CLONING OF A CDNA CODING FOR NEUROFIBROMATOSIS TYPE-1 PROTEIN ISOFORM LACKING THE DOMAIN RELATED TO RAS GTPASE-ACTIVATING PROTEIN ラスト(シニア)オーサー / 責任著者

H SUZUKI , K TAKAHASHI , Y KUBOTA , S SHIBAHARA

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 187 (2) 984 - 990 1992-09

181.

DOWNSTREAM REGION OF THE HUMAN TYROSINASE-RELATED PROTEIN GENE ENHANCES ITS PROMOTER ACTIVITY ラスト(シニア)オーサー / 責任著者

K SHIBATA , K TAKEDA , Y TOMITA , H TAGAMI , S SHIBAHARA

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 184 (2) 568 - 575 1992-04

182.

Decreased expression of neurotrophin-3 mRNA in the rat hippocampus following transient forebrain ischemia ラスト(シニア)オーサー

Atsushi Takeda , Hiroshi Onodera , Yasundo Yamasaki , Katsutoshi Furukawa , Kyuya Kogure , Masuo Obinata , Shigeki Shibahara

Brain Research 569 (1) 177 - 180 1992-01-08

183.

MOLECULAR-BASES OF TYROSINASE-NEGATIVE OCULOCUTANEOUS ALBINISM - A SINGLE BASE INSERTION OR A MISSENSE POINT MUTATION IN THE TYROSINASE GENE

Y TOMITA , A TAKEDA , J MATSUNAGA , S OKINAGA , S SHIBAHARA , H TAGAMI

PIGMENT CELL RESEARCH Suppl 2 96 - 100 1992

184.

IDENTIFICATION OF MUTATIONS IN THE PIGMENT CELL-SPECIFIC GENE LOCATED AT THE BROWN LOCUS IN MOUSE 筆頭著者 / 責任著者

S SHIBAHARA , Y TOMITA , M YOSHIZAWA , K SHIBATA , H TAGAMI

PIGMENT CELL RESEARCH Suppl 2 90 - 95 1992

185.

Mutations of the Tyrosinase Gene in Oculocutaneous Albinism 筆頭著者

SHIGEKI SHIBAHARA

Pigment Cell Research 5 (5) 279 - 283 1992

186.

Cloning and sequence analysis of the tyrosinase gene from a patient with tyrosinase-positive oculocutaneous albinism

Jun Matsunaga , Atsushi Takeda , Yasushi Tomita , Masahiro Hara , Shigeki Shibahara , Hachiro Tagami

Journal of Dermatological Science 3 (3) 181 - 185 1992

187.

Phylogeny of Regulatory Regions of Vertebrate Tyrosinase Genes

HIROAKI YAMAMOTO , TOSHIYUKI KUDO , NORIO MASUKO , HIROHITO MIURA , SHIGERU SATO , MIKA TANAKA , SATOSHI TANAKA , SAKAE TAKEUCHI , SHIGEKI SHIBAHARA , TAKUJI TAKEUCHI

Pigment Cell Research 5 (5) 284 - 294 1992

188.

BRAIN-TUMORS PREDOMINANTLY EXPRESS THE NEUROFIBROMATOSIS TYPE-1 GENE TRANSCRIPTS CONTAINING THE 63 BASE INSERT IN THE REGION CODING FOR GTPASE ACTIVATING PROTEIN-RELATED DOMAIN ラスト(シニア)オーサー / 責任著者

Y SUZUKI , H SUZUKI , T KAYAMA , T YOSHIMOTO , S SHIBAHARA

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 181 (3) 955 - 961 1991-12

189.

SEQUENTIAL ACTIVATION OF GENES FOR HEME PATHWAY ENZYMES DURING ERYTHROID-DIFFERENTIATION OF MOUSE FRIEND VIRUS-TRANSFORMED ERYTHROLEUKEMIA-CELLS

H FUJITA , M YAMAMOTO , T YAMAGAMI , N HAYASHI , TR BISHOP , H DEVERNEUIL , T YOSHINAGA , S SHIBAHARA , R MORIMOTO , S SASSA

BIOCHIMICA ET BIOPHYSICA ACTA 1090 (3) 311 - 316 1991-11

190.

STRUCTURAL ORGANIZATION OF THE PIGMENT CELL-SPECIFIC GENE LOCATED AT THE BROWN LOCUS IN MOUSE - ITS PROMOTER ACTIVITY AND ALTERNATIVELY SPLICED TRANSCRIPTS 筆頭著者 / 責任著者

S SHIBAHARA , H TAGUCHI , RM MULLER , K SHIBATA , T COHEN , Y TOMITA , H TAGAMI

JOURNAL OF BIOLOGICAL CHEMISTRY 266 (24) 15895 - 15901 1991-08

191.

NUCLEOTIDE-SEQUENCE OF THE PUTATIVE HUMAN TYROSINASE PSEUDOGENE ラスト(シニア)オーサー / 責任著者

A TAKEDA , J MATSUNAGA , Y TOMITA , H TAGAMI , S SHIBAHARA

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 163 (4) 295 - 297 1991-04

192.

THE MONOCLONAL-ANTIBODIES TMH-1 AND TMH-2 SPECIFICALLY BIND TO A PROTEIN ENCODED AT THE MURINE B-LOCUS, NOT TO THE AUTHENTIC TYROSINASE ENCODED AT THE C-LOCUS

Y TOMITA , S SHIBAHARA , A TAKEDA , S OKINAGA , J MATSUNAGA , H TAGAMI

JOURNAL OF INVESTIGATIVE DERMATOLOGY 96 (4) 500 - 504 1991-04

193.

NUCLEOTIDE-SEQUENCE OF THE CDNA-ENCODING L-HISTIDINE DECARBOXYLASE DERIVED FROM HUMAN BASOPHILIC LEUKEMIA-CELL LINE, KU-812-F

K YAMAUCHI , R SATO , Y TANNO , Y OHKAWARA , K MAEYAMA , T WATANABE , K SATOH , M YOSHIZAWA , S SHIBAHARA , T TAKISHIMA

NUCLEIC ACIDS RESEARCH 18 (19) 5891 - 5891 1990-10

194.

MOLECULAR-BASIS OF TYROSINASE-NEGATIVE OCULOCUTANEOUS ALBINISM - A SINGLE BASE MUTATION IN THE TYROSINASE GENE CAUSING ARGININE TO GLUTAMINE SUBSTITUTION AT POSITION-59 ラスト(シニア)オーサー / 責任著者

A TAKEDA , Y TOMITA , J MATSUNAGA , H TAGAMI , S SHIBAHARA

JOURNAL OF BIOLOGICAL CHEMISTRY 265 (29) 17792 - 17797 1990-10

195.

NUCLEOTIDE-SEQUENCE OF THE CDNA-ENCODING HUMAN TYROSINASE-RELATED PROTEIN ラスト(シニア)オーサー / 責任著者

T COHEN , RM MULLER , Y TOMITA , S SHIBAHARA

NUCLEIC ACIDS RESEARCH 18 (9) 2807 - 2808 1990-05

196.

A POINT MUTATION IN THE TYROSINASE GENE OF BALB/C ALBINO MOUSE CAUSING THE CYSTEINE-]SERINE SUBSTITUTION AT POSITION 85 筆頭著者 / 責任著者

S SHIBAHARA , S OKINAGA , Y TOMITA , A TAKEDA , H YAMAMOTO , M SATO , T TAKEUCHI

EUROPEAN JOURNAL OF BIOCHEMISTRY 189 (2) 455 - 461 1990-04

197.

INTERACTION OF UPSTREAM STIMULATORY FACTOR WITH THE HUMAN HEME OXYGENASE GENE PROMOTER ラスト(シニア)オーサー / 責任著者

M SATO , S ISHIZAWA , T YOSHIDA , S SHIBAHARA

EUROPEAN JOURNAL OF BIOCHEMISTRY 188 (2) 231 - 237 1990-03

198.

MOLECULAR ANALYSIS OF THE DNA SEGMENTS CROSS-HYBRIDIZABLE TO THE TYROSINASE GENE IN PATIENTS AFFECTED WITH OCULOCUTANEOUS ALBINISM ラスト(シニア)オーサー

A TAKEDA , J MATSUNAGA , Y TOMITA , H TAGAMI , S SHIBAHARA

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 159 (4) 333 - 340 1989-12

199.

HUMAN OCULOCUTANEOUS ALBINISM CAUSED BY SINGLE BASE INSERTION IN THE TYROSINASE GENE ラスト(シニア)オーサー / 責任著者

Y TOMITA , A TAKEDA , S OKINAGA , H TAGAMI , S SHIBAHARA

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 164 (3) 990 - 996 1989-11

200.

FUNCTIONAL-ANALYSIS OF THE CDNA-ENCODING HUMAN TYROSINASE PRECURSOR ラスト(シニア)オーサー / 責任著者

A TAKEDA , Y TOMITA , S OKINAGA , H TAGAMI , S SHIBAHARA

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 162 (3) 984 - 990 1989-08

201.

LEVELS OF TYROSINASE AND ITS MESSENGER-RNA IN COAT-COLOR MUTANTS OF C57BL 10J CONGENIC MICE - EFFECTS OF GENIC SUBSTITUTION AT THE AGOUTI, BROWN, ALBINO, DILUTE, AND PINK-EYED-DILUTION LOCI

HB TAMATE , T HIROBE , K WAKAMATSU , S ITO , S SHIBAHARA , K ISHIKAWA

JOURNAL OF EXPERIMENTAL ZOOLOGY 250 (3) 304 - 311 1989-06

202.

TRANSCRIPTIONAL CONTROL OF THE RAT HEME OXYGENASE GENE BY A NUCLEAR-PROTEIN THAT INTERACTS WITH ADENOVIRUS-2 MAJOR LATE PROMOTER ラスト(シニア)オーサー / 責任著者

M SATO , Y FUKUSHI , S ISHIZAWA , S OKINAGA , RM MULLER , S SHIBAHARA

JOURNAL OF BIOLOGICAL CHEMISTRY 264 (17) 10251 - 10260 1989-06

203.

TRANSCRIPTIONAL ACTIVATION OF THE HEME OXYGENASE GENE BY HEME AND CADMIUM IN MOUSE HEPATOMA-CELLS

J ALAM , S SHIBAHARA , A SMITH

JOURNAL OF BIOLOGICAL CHEMISTRY 264 (11) 6371 - 6375 1989-04

204.

STRUCTURAL ORGANIZATION OF THE HUMAN HEME OXYGENASE GENE AND THE FUNCTION OF ITS PROMOTER 筆頭著者 / 責任著者

S SHIBAHARA , M SATO , RM MULLER , T YOSHIDA

EUROPEAN JOURNAL OF BIOCHEMISTRY 179 (3) 557 - 563 1989-02

205.

MOLECULAR-BASIS FOR THE HETEROGENEITY OF HUMAN TYROSINASE 筆頭著者 / 責任著者

S SHIBAHARA , Y TOMITA , H TAGAMI , RM MULLER , T COHEN

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 156 (4) 403 - 414 1988-12

206.

HUMAN HEME OXYGENASE CDNA AND INDUCTION OF ITS MESSENGER-RNA BY HEMIN ラスト(シニア)オーサー / 責任著者

T YOSHIDA , P BIRO , T COHEN , RM MULLER , S SHIBAHARA

EUROPEAN JOURNAL OF BIOCHEMISTRY 171 (3) 457 - 461 1988-02

207.

TRANSCRIPTIONAL REGULATION OF A PLASMINOGEN-ACTIVATOR GENE BY CYCLIC-AMP IN A HOMOLOGOUS CELL-FREE SYSTEM - INVOLVEMENT OF CYCLIC AMP-DEPENDENT PROTEIN-KINASE IN TRANSCRIPTIONAL CONTROL

J NAKAGAWA , D VONDERAHE , D PEARSON , BA HEMMINGS , S SHIBAHARA , Y NAGAMINE

JOURNAL OF BIOLOGICAL CHEMISTRY 263 (5) 2460 - 2468 1988-02

208.

Tenascin: cDNA cloning and induction by TGF-beta.

Pearson C A , Pearson D , Shibahara S , Hofsteenge J , Chiquet-Ehrismann R

EMBO J 7 (10) 2977 - 2982 1988

209.

EXPRESSION OF HEME OXYGENASE GENE IN RAT AND HUMAN-LIVER

NG ABRAHAM , JHC LIN , SM MITRIONE , ML SCHWARTZMAN , RD LEVERE , S SHIBAHARA

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 150 (2) 717 - 722 1988-01

210.

Expression of heme oxygenase in hemopoiesis. (Adv Exp Med Biol)

Abraham N G , Mitrione S M , Hodgson W J , Levere R D , Shibahara S

Adv Exp Med Biol 241 97 - 116 1988

211.

Regulation of heme oxygenase gene expression. (Semin Hematol)

Shibahara S

Semin Hematol 25 (4) 370 - 376 1988

212.

TRANSCRIPTIONAL CONTROL OF RAT HEME OXYGENASE BY HEAT-SHOCK 筆頭著者 / 責任著者

S SHIBAHARA , RM MULLER , H TAGUCHI

JOURNAL OF BIOLOGICAL CHEMISTRY 262 (27) 12889 - 12892 1987-09

213.

NUCLEOTIDE-SEQUENCE AND ORGANIZATION OF THE RAT HEME OXYGENASE GENE ラスト(シニア)オーサー / 責任著者

RM MULLER , H TAGUCHI , S SHIBAHARA

JOURNAL OF BIOLOGICAL CHEMISTRY 262 (14) 6795 - 6802 1987-05

214.

CLONING AND EXPRESSION OF CDNA-ENCODING MOUSE TYROSINASE 筆頭著者 / 責任著者

S SHIBAHARA , Y TOMITA , T SAKAKURA , C NAGER , B CHAUDHURI , R MULLER

NUCLEIC ACIDS RESEARCH 14 (6) 2413 - 2427 1986-03

215.

CLONING AND SEQUENCE-ANALYSIS OF HUMAN GENOMIC DNA ENCODING GAMMA-SUBUNIT PRECURSOR OF MUSCLE ACETYLCHOLINE-RECEPTOR 筆頭著者

S SHIBAHARA , T KUBO , HJ PERSKI , H TAKAHASHI , M NODA , S NUMA

EUROPEAN JOURNAL OF BIOCHEMISTRY 146 (1) 15 - 22 1985

216.

CLONING AND SEQUENCE-ANALYSIS OF CDNA FOR RAT CORTICOTROPIN-RELEASING FACTOR PRECURSOR

H JINGAMI , N MIZUNO , H TAKAHASHI , S SHIBAHARA , Y FURUTANI , H IMURA , S NUMA

FEBS LETTERS 191 (1) 63 - 66 1985

217.

Cloning and expression of cDNA for rat heme oxygenase. 筆頭著者

Shibahara S , Muller R , Taguchi H , Yoshida T

Proc Natl Acad Sci U S A 82 (23) 7865 - 7869 1985

218.

ELASTIN MESSENGER-RNA LEVELS DURING FETAL DEVELOPMENT OF SHEEP NUCHAL LIGAMENT AND LUNG - HYBRIDIZATION TO COMPLEMENTARY AND CLONED DNA

JM DAVIDSON , S SHIBAHARA , C BOYD , ML MASON , P TOLSTOSHEV , RG CRYSTAL

BIOCHEMICAL JOURNAL 220 (3) 653 - 663 1984

219.

SHEEP ELASTIN GENES - ISOLATION AND PRELIMINARY CHARACTERIZATION OF A 9.9-KILOBASE GENOMIC CLONE

JM DAVIDSON , S SHIBAHARA , MP SCHAFER , M HARRISON , C LEACH , P TOLSTOSHEV , RG CRYSTAL

BIOCHEMICAL JOURNAL 220 (3) 643 - 652 1984

220.

CLONING AND SEQUENCE-ANALYSIS OF CDNA FOR OVINE CORTICOTROPIN-RELEASING FACTOR PRECURSOR

Y FURUTANI , Y MORIMOTO , S SHIBAHARA , M NODA , H TAKAHASHI , T HIROSE , M ASAI , S INAYAMA , H HAYASHIDA , T MIYATA , S NUMA

NATURE 301 (5900) 537 - 540 1983

221.

ISOLATION AND SEQUENCE-ANALYSIS OF THE HUMAN CORTICOTROPIN-RELEASING FACTOR PRECURSOR GENE 筆頭著者

S SHIBAHARA , Y MORIMOTO , Y FURUTANI , M NOTAKE , H TAKAHASHI , S SHIMIZU , S HORIKAWA , S NUMA

EMBO JOURNAL 2 (5) 775 - 779 1983

222.

REGULATION OF ELASTIN SYNTHESIS IN DEVELOPING SHEEP NUCHAL LIGAMENT BY ELASTIN MESSENGER-RNA LEVELS

JM DAVIDSON , K SMITH , S SHIBAHARA , P TOLSTOSHEV , RG CRYSTAL

JOURNAL OF BIOLOGICAL CHEMISTRY 257 (2) 747 - 754 1982

223.

DEVELOPMENTAL REGULATION OF ELASTIN SYNTHESIS

JM DAVIDSON , S SHIBAHARA , K SMITH , RG CRYSTAL

CONNECTIVE TISSUE RESEARCH 8 (3-4) 209 - 212 1981

224.

MODULATION OF TROPOELASTIN PRODUCTION AND ELASTIN MESSENGER RIBONUCLEIC-ACID ACTIVITY IN DEVELOPING SHEEP LUNG 筆頭著者

S SHIBAHARA , JM DAVIDSON , K SMITH , RG CRYSTAL

BIOCHEMISTRY 20 (23) 6577 - 6584 1981

225.

BRONCHIAL RESPONSE TO METHACHOLINE AND HISTAMINE IN MONKEYS WITH BETA-ADRENERGIC-BLOCKADE

S MUE , S SHIBAHARA , S SUZUKI , M TAKAHASHI , W HIDA , K YAMAUCHI , T OHMI , T SASAKI , T TAKISHIMA

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 65 (5) 338 - 345 1980

226.

Intracellular site of synthesis of microsomal heme oxygenase in pig spleen. 筆頭著者

Shibahara S , Yoshida T , Kikuchi G

J Biochem (Tokyo) 88 (1) 45 - 50 1980

227.

Influence of metoprolol on hemodynamics and respiratory function in asthmatic patients.

Mue S , Sasaki T , Shibahara S , Takahashi M , Ohmi T , Yamauchi K , Suzuki S , Hida W , Takishima T

Int J Clin Pharmacol Biopharm 17 (8) 346 - 350 1979

228.

Mechanism of increase of heme oxygenase activity induced by hemin in cultured pig alveolar macrophages. 筆頭著者

Shibahara S , Yoshida T , Kikuchi G

Arch Biochem Biophys 197 (2) 607 - 617 1979

229.

Effects of adrenergic agonists and antagonists on immediate cutaneous reactions in bronchial asthma.

Ohmi T , Mue S , Takahashi M , Shibahara S , Yamauchi K , Tamura G , Fujimoto S , Chen H C , Takishima T

Tohoku J Exp Med 127 (2) 197 - 198 1979

230.

The relationship between the arterial level of angiotensin-converting enzymes and arterial gas tension in bronchial asthma.

Mue S , Takahashi M , Ohmi T , Okayama H , Shibahara S , Yamauchi K , Fujimoto S , Tamura G , Takishima T

Ann Allergy 43 (3) 179 - 186 1979

231.

Serum angiotensin converting enzyme level in bronchial asthma.

Mue S , Takahashi M , Ohmi T , Shibahara S , Yamauchi K , Fujimoto S , Okayama H , Takishima T

Ann Allergy 40 (1) 51 - 57 1978

232.

Induction of heme oxygenase by hemin in cultured pig alveolar macrophages. 筆頭著者

Shibahara S , Yoshida T , Kikuchi G

Arch Biochem Biophys 188 (2) 243 - 250 1978

233.

Serum angiotensin converting enzyme activity in human bronchial asthma.

Takahashi M , Mue S , Ohmi T , Shibahara S , Yamauchi K

Tohoku J Exp Med 121 (2) 195 - 196 1977

234.

Leukocyte adenosine triphosphatase activity in human bronchial asthma.

Mue S , Ise T , Shibahara S , Takahashi M , Takishima T

Tohoku J Exp Med 119 (3) 257 - 264 1976

235.

Leukocyte cyclic-3', 5'-nucleotide phosphodiesterase activity in human bronchial asthma.

Mue S , Ise T , Shibahara S , Takahashi M , Ono Y

Ann Allergy 37 (3) 201 - 207 1976

Misc (92)

1.

A Message for Young Authors: The Past 100 Years and Future of the Tohoku Journal of Experimental Medicine. ラスト(シニア)オーサー

Kazuhiro Takahashi , Shigeki Shibahara

The Tohoku journal of experimental medicine 250 (1) 1 - 3 2020-01

2.

100 Years of the Tohoku Journal of Experimental Medicine, and the Tohoku Medical Megabank Project in the Japanese New Era, Reiwa

Takahashi Kazuhiro , Shibahara Shigeki

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 248 (1) 1 - 2 2019-05

3.

(Pro)renin receptor in melanoma

Ohba Koji , Suzuki Tamio , Takeda Kazuhisa , Shibahara Shigeki , Takahashi Kazuhiro

CANCER SCIENCE 109 343 - 2018-01

4.

南山堂 医学大辞典 第20版

柴原茂樹

- 2015

5.

ヒト赤芽球特異的5-アミノレブリン酸合成酵素遺伝子の新たな赤芽球特異的エンハンサーの同定

古山 和道 , 金子 桐子 , 藤原 亨 , 張替 秀郎 , 柴原 茂樹

日本生化学会大会プログラム・講演要旨集 85回 3T12 - 08 2012-12

6.

東北大学医学系研究科・医学部 東日本大震災記録集

柴原茂樹 , 他多数

東北大学大学院医学系研究科・医学部 - 2012

7.

東北大学医学系研究科・医学部 東日本大震災記録集

柴原茂樹 , 他多数

東北大学大学院医学系研究科・医学部 - 2012

8.

赤芽球特異的5-アミノレブリン酸合成酵素のカルボキシル末端は内因性抑制ドメインとして機能する

Senkottuvelan Kadirvel , 古山 和道 , 金子 桐子 , 張替 秀郎 , 柴原 茂樹

日本生化学会大会プログラム・講演要旨集 84回 2T10a - 2 2011-09

9.

Pigment production for maintaining epidermal homeostasis: lessons from keratinocytes and melanocytes

S. Shibahara , K. Takeda

PIGMENT CELL & MELANOMA RESEARCH 24 (4) 760 - 760 2011-08

10.

The 2011 Tohoku Earthquake and Devastating Tsunami

Shigeki Shibahara

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 223 (4) 305 - 307 2011-04

11.

The Upcoming 90(th) Anniversary of the Tohoku Journal of Experimental Medicine

Shigeki Shibahara

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 218 (3) 161 - 163 2009-07

12.

生体のホメオスタシスの維持におけるヘムの役割 酸素恒常性の制御因子としてのヘム 換気-灌流ミスマッチに関する新たな知見(Heme as a regulator of oxygen homeostasis: New insights for ventilation-perfusion mismatch)

柴原 茂樹 , 丸山 芳夫 , 武田 和久 , 吉澤 美季 , 古山 和道

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 81回・31回 2S15 - 8 2008-11

13.

低酸素は肝癌由来細胞株におけるヘム生合成系酵素の発現を抑制する

パトリック・バルガス , 古山 和道 , 金子 桐子 , 柴原 茂樹

生化学 80 (6) 592 - 592 2008-06

14.

Analysis of multiple function of Mitf in chick RPE development

Nagaharu Tsukiji , Kazuhisa Takeda , Shigeki Shibahara , Hiroaki Yamamoto

PIGMENT CELL & MELANOMA RESEARCH 21 (2) 307 - 307 2008-04

15.

Epidermal homeostasis revisited with heme catabolism: lessons from newborns

Shigeki Shibahara

PIGMENT CELL & MELANOMA RESEARCH 21 (2) 288 - 288 2008-04

16.

The functional expression of Heme Oxygenase-1 in normal human epidermis

I. Numata , S. Shibahara , S. Aiba

JOURNAL OF INVESTIGATIVE DERMATOLOGY 128 S101 - S101 2008-04

17.

Prostaglandin D2 represses the growth of human melanoma cells through a mechanism independent of prostaglandin D2 receptors

Kazuhisa Takeda , Naho Takahashi , Shigeki Shibahara

PIGMENT CELL & MELANOMA RESEARCH 21 (2) 314 - 314 2008-04

18.

低酸素刺激によるヘモグロビン合成誘導機構

金子桐子 , 古山和道 , 柴原茂樹

生化学 4P-0419 - 2008

19.

化学物質による表皮ヘムオキシゲナーゼ1の発現解析

沼田 郁子 , 武田 和久 , 伊藤 由美子 , 齋藤 るみ子 , 古山 和道 , 柴原 茂樹 , 相場 節也

Journal of Environmental Dermatology and Cutaneous Allergology 1 (Suppl.1) 126 - 126 2007-12

20.

Mitf regulates differentiation and cell proliferation ofthe RPE

Nagaharu Tsukiji , Ichiro Yajima , Goding Colin , Kazuhisa Takeda , Shigeki Shibahara

ZOOLOGICAL SCIENCE 23 (12) 1177 - 1177 2006-12

21.

Hypoxia induces hemoglobin production in human erythroleukemia cells by increasing the secretion of transforming growth factor-beta 1 and the expression of mitoferrin.

Kaneko Kiriko , Furuyama Kazumichi , Aburatani Hiroyuki , Shibahara Shigeki

BLOOD 108 (11) 447A - 2006-11-16

22.

低酸素刺激による赤芽球系細胞遺伝子発現プロファイルの変化の検討 低酸素刺激はいかにしてヘモグロビン合成を促進するのか?

金子桐子 , 古山和道 , ZhangYongzhao , Vargas V.Patrick D , DingYuanying , 油谷浩幸 , 柴原茂樹

生化学 78 (8) 788 - 788 2006-08

23.

Hypoxemia and attenuated hypoxic ventilatory responses in mice lacking heme oxygenase-2 - Evidencefor a novel role of heme oxygenase-2 as an oxygen sensor

YZ Zhang , K Furuyama , T Adachi , K Ishikawa , H Matsumoto , T Masuda , K Ogawa , K Takeda , M Yoshizawa , H Ogawa , Y Maruyama , W Hida , S Shibahara

ARTERIAL CHEMORECEPTORS 580 161 - 166 2006

24.

Hypoxemia and attenuated hypoxic ventilatory responses in mice lacking heme oxygenase-2: Evidence for a novel role of heme oxygenase-2 as an oxygen sensor

Yongzhao Zhang , Kazumichi Furuyama , Tetsuya Adachi , Kazunobu Ishikawa , Hayato Matsumoto , Takayuki Masuda , Kazuhiro Ogawa , Kazuhisa Takeda , Miki Yoshizawa , Hiromasa Ogawa , Yukio Maruyama , Wataru Hida , Shigeki Shibahara

Advances in Experimental Medicine and Biology 580 161 - 166 2006

25.

Suppression of erythroid-specific 5-aminolevulinate synthase using short-interfering RNA alters iron metabolism and inhibits terminal differentiation of human erythroleukemia cells.

K Furuyama , K Kaneko , YZ Zhang , PD Vargas , S Sassa , S Shibahara

BLOOD 104 (11) 453A - 454A 2004-11

26.

3T3-L1細胞の脂肪細胞分化におけるアドレノメデュリン遺伝子の発現制御機構の解析

李茵, 張えん , 武田和久 , 古山和道 , 柴原茂樹 , 高橋和広

日本内分泌学会雑誌 80 (2) 493 - 493 2004-09

27.

Differential regulation of stress response genes and transcription factors by NO donors

K Ogawa , H Fujita , S Shibahara , T Yanagisawa

JOURNAL OF PHARMACOLOGICAL SCIENCES 94 241P - 241P 2004

28.

ウロコルチンIII/ストレスコピンのヒト組織における発現と血中及び尿中における存在

高橋和広 , 戸恒和人 , 在原善英 , 村上治 , 猿田雅之 , 笹野公伸 , 柴原茂樹

日本内科学会雑誌 93 (Suppl.) 182 - 182 2004

29.

Late-onset X-linked sideroblastic anemia following hemodialysis

K Furuyama , H Harigae , C Kinoshita , T Shimada , K Miyaoka , C Kanda , Y Maruyama , S Shibahara , S Sassa

BLOOD 101 (11) 4623 - 4624 2003-06

30.

Repression of heme oxygenase-1 expression as a defense strategy in humans

S Shibahara , M Nakayama , T Kitamuro , R Udono-Fujimori , K Takahashi

EXPERIMENTAL BIOLOGY AND MEDICINE 228 (5) 472 - 473 2003-05

31.

[Heme oxygenase-1: for whom is its expression suppressed?] (Seikagaku)

Takahashi Kazuhiro , Shibahara Shigeki

Seikagaku 75 (3) 213 - 218 2003-03

32.

Decreased expression of adrenomedullin during adipocyte-differentiation of 3T3-L1 cells

Y Li , K Totsune , K Takeda , K Furuyama , S Shibahara , K Takahashi

HYPERTENSION RESEARCH 26 S41 - S44 2003-02

33.

副腎腫瘍におけるウロテンシンIIの発現と細胞増刺激作用

高橋和広 , 戸恒和人 , 村上治 , 佐藤善英 , 野城孝夫 , 柴原茂樹

日本内科学会雑誌 92 (Suppl.) 232 - 232 2003

34.

ヒト脳組織と心臓におけるウロコルチンIII/ストレスコピンの検討

高橋和広 , 戸恒和人 , 在原善英 , 村上治 , 猿田雅之 , 笹野公伸 , 柴原茂樹

日本内分泌学会雑誌 79 (1) 200 - 200 2003

35.

3T3-L1細胞の脂肪細胞分化時におけるアドレノメデュリン発現の低下

李茵 , 高橋和広 , 戸恒和人 , 村上治 , 柴原茂樹

日本内分泌学会雑誌 79 (1) 156 - 156 2003

36.

新たなCRFファミリーペプチド,ウロコルチンIII/ストレスコピンの心臓における発現

高橋和広 , 戸恒和人 , 在原善英 , 村上治 , 猿田雅之 , 笹野公伸 , 今井潤 , 柴原茂樹

日本内分泌学会雑誌 79 (2) 541 - 541 2003

37.

ヒトとラット組織におけるウロコルチンIII/ストレスコピンの検討

高橋和広 , 戸恒和人 , 在原善英 , 村上治 , 猿田雅之 , 笹野公伸 , 柴原茂樹

日本内分泌学会雑誌 79 (2) 366 - 366 2003

38.

環境医学

柴原茂樹

臨床化学 32 (1) 21 - 24 2003

39.

医学書院 医学大辞典

柴原茂樹

- 2003

40.

ヘム関連タンパク質の多様性 ー人類の生存戦略を探るー 生化学の特集号を編集した。 (生化学)

柴原茂樹

生化学 75 (3) 173 - 241 2003

41.

Microphthalmia-associated transcription factor in the Wnt signaling pathway. (Pigment Cell Res)

Saito Hideo , Yasumoto Ken-Ichi , Takeda Kazuhisa , Takahashi Kazuhiro , Yamamoto Hiroaki , Shibahara Shigeki

Pigment Cell Res 16 (3) 261 - 265 2003

42.

環境医学

柴原茂樹

臨床化学 32 (1) 21 - 24 2003

43.

医学書院 医学大辞典

柴原茂樹

- 2003

44.

ヘム関連タンパク質の多様性 ー人類の生存戦略を探るー 生化学の特集号を編集した。 (生化学)

柴原茂樹

生化学 75 (3) 173 - 241 2003

45.

Repression of heme oxygenase-1 expression as a defense strategy in humans

Shigeki Shibahara , Masaharu Nakayama , Tomomi Kitamuro , Reiko Udono-Fujimori , Kazuhiro Takahashi

Experimental Biology and Medicine 228 (5) 472 - 473 2003

46.

R452C/H mutation of the erythroid-specific 5-aminolevulinate synthase in patients with X-linked sideroblastic anemia: Mutation does not affect enzymatic activity.

K Furuyama , H Harigae , T Heller , E Minder , BCJ Hamel , S Shibahara , S Sassa

BLOOD 100 (11) 658A - 658A 2002-11

47.

ミトコンドリアと疾患 鉄芽球性貧血と赤血球型アミノレブリン酸合成酵素の翻訳後調節

古山和道 , 柴原茂樹 , 佐々茂

生化学 74 (8) 675 - 675 2002-08

48.

Heme-regulated transcription factor Bach1

Kazuhiro Ogawa , Kazuhiko Igarashi , Chiaki Nishitani , Shigeki Shibahara , Hiroyoshi Fujita

Journal of Health Science 48 (1) 1 - 6 2002-02

49.

種々副腎腫瘍の腫瘍組織におけるウロテンシンIIの発現

高橋和広 , 戸恒和人 , 村上治 , 曽根正彦 , 野城孝夫 , 柴原茂樹

日本内分泌学会雑誌 78 (1) 146 - 146 2002

50.

培養ヒトグリオブラストーマ細胞からのアドレノメデュリンとエンドセリン-1の産生・分泌 グルココルチコイドの効果

高橋和広 , 藤盛玲子 , 戸恒和人 , 村上治 , 柴原茂樹

生化学 74 (8) 749 - 749 2002

51.

ヒト腎細胞癌培養細胞株VMRC-RCWにおけるウロテンシンII,アドレノメデュリンとエンドセリンの発現と細胞増殖への効果

高橋和広 , 戸恒和人 , 在原善英 , 村上治 , 柴原茂樹

日本内分泌学会雑誌 78 (2) 451 - 451 2002

52.

培養ヒトグリオブラストーマ細胞からのアドレノメデュリンとエンドセリン-1の産生・分泌 グルココルチコイドの効果

高橋和広 , 藤盛玲子 , 戸恒和人 , 在原善英 , 村上治 , 柴原茂樹

日本内分泌学会雑誌 78 (2) 312 - 312 2002

53.

色即是空の分子生物学

柴原茂樹

分子呼吸病,先端医学社 6 (2) 76 - 77 2002

54.

ヘムオキシゲナーゼ

北室知巳 , 柴原茂樹

分子呼吸病,先端医学社 6 (2) 5(93)-11(99) - 2002

55.

褐色細胞腫・神経芽細胞腫の腫瘍組織におけるmelanin-concentrating hormoneレセプターmRNAの発現

高橋和広 , 柴原茂樹 , 戸恒和人 , 村上治 , 佐藤文俊 , 在原善英 , 林富 , 野城孝夫 , 笹野公伸

日本内科学会雑誌 90 (臨増) 258 - 258 2001

56.

種々腫瘍の培養細胞におけるウロテンシンIImRNAの発現とヒト副腎皮質癌細胞株SW-13からのウロテンシンII免疫活性物質の分泌

高橋和広 , 戸恒和人 , 在原善英 , 曽根正彦 , 村上治 , 柴原茂樹

日本内分泌学会雑誌 77 (1) 149 - 149 2001

57.

低酸素下におけるアドレノメデュリンとその受容体構成要素RAMP2の発現に関する検討

北室知巳 , 高橋和広 , 中山雅晴 , 戸恒和人 , 村上治 , 飛田渉 , 白土邦男 , 柴原茂樹

生化学 73 (8) 1008 - 1008 2001

58.

ヒト脳組織,副腎及び副腎腫瘍におけるプロラクチン放出ペプチド受容体mRNAの発現

高橋和広 , 戸恒和人 , 曽根正彦 , 在原善英 , 野城孝夫 , 村上治 , 笹野公伸 , 柴原茂樹

日本内分泌学会雑誌 77 (2) 307 - 307 2001

59.

ヒト腫瘍の種々培養細胞におけるアドレノメデュリン・エンドセリン-1・ウロテンシンIIの発現

高橋和広 , 戸恒和人 , 北室知巳 , 曽根正彦 , 在原善英 , 村上治 , 柴原茂樹

日本内分泌学会雑誌 77 (2) 434 - 434 2001

60.

Adrenomedullin in cultured human retinal pigment epithelial cells.

T Udono , K Takahashi , M Nakayama , O Murakami , YK Durlu , M Tamai , S Shibahara

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 41 (4) S603 - S603 2000-03

61.

【内分泌現象の進化 From Comparative to General】 ヒトにおけるMelanin-concentrating hormone

高橋和広 , 曽根正彦 , 村上治 , 戸恒和人 , 在原善英 , 柴原茂樹 , 笹野公伸 , 毛利虎一

日本内分泌学会雑誌 76 (1) 50 - 50 2000

62.

ヒト脳組織と褐色細胞腫・神経芽細胞腫の腫瘍組織におけるMCHレセプターmRNAの発現の検討

高橋和広 , 曽根正彦 , 柴原茂樹 , 村上治 , 戸恒和人 , 佐藤文俊 , 笹野公伸 , 林富 , 野城孝夫 , 毛利虎一

東北医学雑誌 112 (1) 106 - 107 2000

63.

ヒト単球性白血病細胞THP-1におけるホルボルエステルによるアドレノメデュリン遺伝子発現誘導の調節機構の解析

中山雅晴 , 高橋和広 , 北室知己 , 村上治 , 白土邦男 , 柴原茂樹

生化学 72 (8) 903 - 903 2000

64.

眼疾患とアドレノメデュリン:増殖性硝子体網膜症における硝子体液中アドレノメデュリン濃度の上昇と網膜色素上皮細胞からの産生・分泌

高橋和広 , 鵜殿徹男 , 村上治 , 戸恒和人 , DurluYK , 玉井信 , 柴原茂樹

日本内分泌学会雑誌 76 (2) 472 - 472 2000

65.

ヒト脳組織における免疫活性Prolactin-releasing peptideの検討

高橋和広 , 佐藤文俊 , 吉野谷彩子 , 在原善英 , 村上治 , 戸恒和人 , 曽根正彦 , 笹野公伸 , 毛利虎一 , 柴原茂樹

日本内分泌学会雑誌 76 (2) 321 - 321 2000

66.

分子生物学から見たメラニン形成

柴原茂樹

太陽紫外線防御研究会学術報告 10 (1) 37 - 44 2000

67.

組織培養工学

武田和久 , 安元研一 , 柴原茂樹

ニュー・サイエンス社 26 (10) 8 (388)-12 (392) - 2000

68.

分子生物学から見たメラニン形成

柴原茂樹

太陽紫外線防御研究会学術報告 10 (1) 37 - 44 2000

69.

組織培養工学

武田和久 , 安元研一 , 柴原茂樹

ニュー・サイエンス社 26 (10) 8 (388)-12 (392) - 2000

70.

培養ヒトアストロサイトからアドレノメデュリンの産生・分泌

高橋和広 , 中山雅晴 , 戸恒和人 , 村上治 , 曽根正彦 , 北室知己 , 吉野谷彩子 , 柴原茂樹

生化学 71 (8) 894 - 894 1999

71.

環境分子応答におけるヘム

小川和宏 , 柴原茂樹 , 藤田博美

日薬理誌 114 255 - 264 1999

72.

小眼球症関連転写因子MITFの構造と機能の多様性

安元研一 , 柴原茂樹

生化学 71 (1) 61 - 64 1999

73.

酸化ストレス、NOとヘムオキシゲナーゼ-1

高橋和広 , 柴原茂樹

医学のあゆみ 188 (13) 1121 - 1124 1999

74.

転写因子 第2版

安元研一 , 柴原茂樹

実験医学 別冊 166 - 167 1999

75.

環境分子応答におけるヘム

小川和宏 , 柴原茂樹 , 藤田博美

日薬理誌 114 255 - 264 1999

76.

小眼球症関連転写因子MITFの構造と機能の多様性

安元研一 , 柴原茂樹

生化学 71 (1) 61 - 64 1999

77.

酸化ストレス、NOとヘムオキシゲナーゼ-1

高橋和広 , 柴原茂樹

医学のあゆみ 188 (13) 1121 - 1124 1999

78.

転写因子 第2版

安元研一 , 柴原茂樹

実験医学 別冊 166 - 167 1999

79.

小眼球症関連転写因子MITFの構造と機能

安元 研一 , 鵜殿 徹男 , 渡邊 健一 , 斎藤 英郎 , 天江 新太郎 , 布施 昇男 , 武田 和久 , 柴原 茂樹

日本分子生物学会年会プログラム・講演要旨集 21 - 1998-12-01

80.

酸化ストレスとheme oxygenase

高橋和広 , 柴原茂樹

The Lung perspectives 6 (1) 74 - 78 1998

81.

バイオテクノロジーにより産生されるヒトに対して生理活性を有する物質に関する研究 神経線維腫症1型等の神経難病の分子制御

高橋 和広 , 柴原 茂樹

持田記念財団研究成果報告集 13 29 - 34 1997-04

82.

Identification of a melanocyte-type promoter of the microphthalmia-associated transcription factor gene

N Fuse , K Yasumoto , H Suzuki , K Takahashi , S Shibahara , M Tamai

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 38 (4) 5295 - 5295 1997-03

83.

ストレスに対する脳の遺伝子応答

柴原茂樹

精神神経薬理シンポジウム 23 (1) 5 - 12 1997

84.

メラニン色素の制御と美白剤の開発

柴原茂樹 , 安元研一

Fragrance Journal 臨時増刊号 (14) 31 - 37 1995

85.

神経線維腫症1型(von Recklinghausen病)の分子生物学

鈴木裕行 , 高橋和広 , 柴原茂樹

神経内科 41 458 - 463 1994

86.

[Molecular genetics of neurofibromatosis type 1] (Nippon Rinsho)

Suzuki H , Takahashi K , Shibahara S

Nippon Rinsho 51 (9) 2457 - 2461 1993-09

87.

特集:分子臨床神経学

鈴木裕行 , 高橋和広 , 柴原茂樹

日本臨床 51 2457 - 2461 1993

88.

A two allele Xbal RFLP at the catalase 2 locus

M. A. Colman , S. Shibahara , B. Kwon , T. Jenkins , M. Ramsay

Nucleic Acids Research 19 (4) 960 - 960 1991-02-25

89.

A 2 ALLELE XBAL RFLP AT THE CATALASE-2 LOCUS

MA COLMAN , S SHIBAHARA , B KWON , T JENKINS , M RAMSAY

NUCLEIC ACIDS RESEARCH 19 (4) 960 - 960 1991-02

90.

サザンブロット法・ノーザンブロット法

柴原茂樹

呼吸 10 (2) 156 - 162 1991

91.

REGULATION OF HEME OXYGENASE GENE-EXPRESSION

S SHIBAHARA

SEIKAGAKU 61 (5) 379 - 385 1989-05

92.

THE PHYSIOLOGICAL SIGNIFICANCE OF HEME OXYGENASE

NG ABRAHAM , JHC LIN , ML SCHWARTZMAN , RD LEVERE , S SHIBAHARA

INTERNATIONAL JOURNAL OF BIOCHEMISTRY 20 (6) 543 - & 1988

書籍・出版物 (19)

1.

医学大辞典 第20版

柴原茂樹

南山堂 2015

2.

色素細胞 第2版 基礎から臨床へ

慶應義塾大学出版会 2015

3.

The Pigmentary System. Physiology and Pathophysiology, 2e

Blackwell Publishing 2006

4.

Heme Oxygenase

Nova Science Publishers 2005

5.

Blood: Principles and Practice of Hematology, 2e

Lippincott Williams &Wilkins 2003

6.

Mechanisms of Suntannig

Martin Dunitz 2002

7.

一般医化学 改訂7版

南山堂 2002

8.

色素細胞

2001

9.

酸化ストレス・レドックスの生化学

共立出版 2000

10.

The Pigmentary System. Physiology and Pathophysiology

1998

11.

Oxygen Homeostasis and Its Dynamics.

1998

12.

MCH and Seizures: Neuromolecular and Neuroendocrine Aspects

1997

13.

Molecular Biology of Hematopoiesis

Plenum Press 1996

14.

ポルフィリン・ヘムの生命科学:遺伝病・がん・工学応用などへの展開

東京化学同人 1995

15.

図説 分子病態学

中外医学社 1995

16.

Regulation of Heme Protein Synthesis

Alpha Med Press 1994

17.

一般医化学

南山堂 1993

18.

新生化学実験講座9 ホルモン1 ペプチドホルモン

東京化学同人 1991

19.

バイオエンジニアリング 最新の話題を集めて

培風館 1991

講演・口頭発表等 (92)

1.

Pigment Production for Maintaining Epidermal Homeostasis: Lessons from Keratinocytes and Melanocytes

21st International Pigment Cell Conference 2011

2.

Pigment Production for Maintaining Epidermal Homeostasis: Lessons from Keratinocytes and Melanocytes

21st International Pigment Cell Conference 2011

3.

Lipocalin-type prostaglandin D synthase as a regulator of the retinoic acid signaling in melanocytes

第23回日本色素細胞学会 2010

4.

Lipocalin-type prostaglandin D synthase as a regulator of the retinoic acid signaling in melanocytes

第23回日本色素細胞学会 2010

5.

Lipocalin-type prostaglandin D synthase sensitizes melanocyte-lineage cells to retinoic acid-mediated proliferation inhibition

第22回日本色素細胞学会 2009

6.

Lipocalin-type prostaglandin D synthase sensitizes melanocyte-lineage cells to retinoic acid-mediated proliferation inhibition

第22回日本色素細胞学会 2009

7.

PROSTAGLANDIN D2 REPRESSES THE GROWTH OF HUMAN MELANOMA CELLS THROUGH A MECHANISM INDEPENDENT OF PROSTAGLANDIN D2 RECEPTORS

20th International Pigment Cell Conference 2008

8.

The MITF history and perspective

20th International Pigment Cell Conference 2008

9.

Epidermal Homeostasis Revisited with Heme Catabolism: Lessons from Newborns

20th International Pigment Cell Conference 2008

10.

低酸素は肝癌由来細胞株におけるヘム生合成系酵素の発現を抑制する

日本生化学会東北支部第74回例会 2008

11.

低酸素刺激によるヘモグロビン合成誘導機構

第81回日本生化学会大会 2008

12.

Prostaglandin D2 as an endogenous inducer of heme oxygenase-1 expression in human retinal pigment epithelial cells

Biochemistry and Molecular Biology 2008 2008

13.

Lipocalin-type prostaglandin D synthase as a potential tumor suppressor in human melanoma cells

Biochemistry and Molecular Biology 2008

14.

Heme as a regulator of oxygen homeostasis: New insights for ventilation-perfusion mismatch

第81回日本生化学会大会 2008

15.

PROSTAGLANDIN D2 REPRESSES THE GROWTH OF HUMAN MELANOMA CELLS THROUGH A MECHANISM INDEPENDENT OF PROSTAGLANDIN D2 RECEPTORS

20th International Pigment Cell Conference 2008

16.

The MITF history and perspective

20th International Pigment Cell Conference 2008

17.

Epidermal Homeostasis Revisited with Heme Catabolism: Lessons from Newborns

20th International Pigment Cell Conference 2008

18.

低酸素は肝癌由来細胞株におけるヘム生合成系酵素の発現を抑制する

日本生化学会東北支部第74回例会 2008

19.

低酸素刺激によるヘモグロビン合成誘導機構

第81回日本生化学会大会 2008

20.

Prostaglandin D2 as an endogenous inducer of heme oxygenase-1 expression in human retinal pigment epithelial cells

Biochemistry and Molecular Biology 2008 2008

21.

Lipocalin-type prostaglandin D synthase as a potential tumor suppressor in human melanoma cells

Biochemistry and Molecular Biology 2008

22.

Heme as a regulator of oxygen homeostasis: New insights for ventilation-perfusion mismatch

第81回日本生化学会大会 2008

23.

低酸素環境におけるヘムオキシゲナーゼの発現制御

分子研研究会「ヘム代謝に関わる酵素の分子科学」 2007

24.

Roles of Lipocalin-type Prostaglandin D Synthase for Non-pigmentary Functions of Melanocytes

2nd Conference of the Asian Society for Pigment Cell Research 2007

25.

Molecular Basis of Phenotypic Variability of Waardenburg Syndrome

2nd Conference of the Asian Society for Pigment Cell Research 2007

26.

Hypoxia regulates the expression of heme oxygenase-2, a potential oxygen sensor

The 5th International Congress Heme Oxygenases 2007 2007

27.

PROSTAGLANDIN D2 REPRESSES THE GROWTH OF HUMAN MELANOMA CELLS; REVISITED WITH MI-BW MOUSE

第21回日本色素細胞学会 2007

28.

Enhanced ventilatory responses to hypoxia and hypercapnia in black-eyed white Mitfmi-bw mice, lacking melanocytes

Biochemistry and Molecular Biology 2007

29.

Hypoxia decreases hydroxymethylbilane synthase expression in hepatic cells: a possible precipitating factor for an attack of acute intermittent porphyria

第80回日本生化学会大会 2007

30.

低酸素環境におけるヘムオキシゲナーゼの発現制御

分子研研究会「ヘム代謝に関わる酵素の分子科学」 2007

31.

Roles of Lipocalin-type Prostaglandin D Synthase for Non-pigmentary Functions of Melanocytes

2nd Conference of the Asian Society for Pigment Cell Research 2007

32.

Molecular Basis of Phenotypic Variability of Waardenburg Syndrome

2nd Conference of the Asian Society for Pigment Cell Research 2007

33.

Hypoxia regulates the expression of heme oxygenase-2, a potential oxygen sensor

The 5th International Congress Heme Oxygenases 2007 2007

34.

PROSTAGLANDIN D2 REPRESSES THE GROWTH OF HUMAN MELANOMA CELLS; REVISITED WITH MI-BW MOUSE

第21回日本色素細胞学会 2007

35.

Enhanced ventilatory responses to hypoxia and hypercapnia in black-eyed white Mitfmi-bw mice, lacking melanocytes

Biochemistry and Molecular Biology 2007

36.

Hypoxia decreases hydroxymethylbilane synthase expression in hepatic cells: a possible precipitating factor for an attack of acute intermittent porphyria

第80回日本生化学会大会 2007

37.

Dynamic changes in the expression levels of heme oxygenases under hypoxia: Two enzymes are better than one

The 50th Anniversary of Oxygenases. The 14th Takeda Science Foundation Symposium on Bioscience 2006

38.

低酸素刺激による赤芽球系細胞遺伝子発現プロファイルの変化の検討;低酸素刺激はいかにしてヘモグロビン合成を促進するのか?

日本生化学会東北支部第72回例会 2006

39.

Lipocalin-type prostaglandin D synthase as a potential tumor suppressor in human melanoma cells

The 20th meeting of the international biochemistry and molecular biology 2006

40.

SOX10 regulates the endothelin receptor type B gene through the unmethylated promoter

The 20th meeting of the international biochemistry and molecular biology 2006

41.

Reduced expression of heme oxygenase-2 protein as a beneficial adaptation to hypoxia in human erythroid cells

The 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress 2006

42.

Hypoxia enhances erythroid differentiation of human erythroleukemia cells through an autocrine mechanism of Transforming Growth Factor β1

The 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress 2006

43.

ヘムオキシゲナーゼの発現抑制とその生理的意義

第3回Heme Oxygenase研究フォーラム 2006

44.

低酸素適応におけるヘムオキシゲナーゼ2の役割

第30回日本鉄バイオサイエンス学会シンポジウム 2006

45.

Augmented ventilatory responses to hypoxia and hypercapnia in black-eyed white Mitf mutant mice

The 13th meeting of the European Society for Pigment Cell Research 2006

46.

Lipocalin-type prostaglandin D synthase as a potential tumor suppressor of human melanoma

The 3rd International Symposium (COE). Novel perspectives in cancer research and translation to the clinics. 2006

47.

SOX10 regulates the endothelin receptor type B gene in human melanocyte-lineage cells

第20回日本色素細胞学会年次学術大会 2006

48.

Dynamic changes in expression of heme oxygenases in mouse organs during hypoxia

日本分子生物学会2006フォーラムMolecular Biology-the next Decade-Conference and Scientific Exhibition 2006

49.

Hypoxia and inflammatory cytokines induce expression of adrenomedullin, a potent vasodilator peptide, through separate mechanisms in cultured human tumor cells

日本分子生物学会2006フォーラム:Molecular Biology-the next Decade-Conference and Scientific Exhibition 2006

50.

Hypoxia induces hemoglobin production in human erythroleukemia cells by increasing the secretion of transforming growth factor -β1 and the expression of mitoferrin.

48th Annual meeting of American Society of Hematology 2006

51.

Dynamic changes in the expression levels of heme oxygenases under hypoxia: Two enzymes are better than one

The 50th Anniversary of Oxygenases. The 14th Takeda Science Foundation Symposium on Bioscience 2006

52.

低酸素刺激による赤芽球系細胞遺伝子発現プロファイルの変化の検討;低酸素刺激はいかにしてヘモグロビン合成を促進するのか?

日本生化学会東北支部第72回例会 2006

53.

Lipocalin-type prostaglandin D synthase as a potential tumor suppressor in human melanoma cells

The 20th meeting of the international biochemistry and molecular biology 2006

54.

SOX10 regulates the endothelin receptor type B gene through the unmethylated promoter

The 20th meeting of the international biochemistry and molecular biology 2006

55.

Reduced expression of heme oxygenase-2 protein as a beneficial adaptation to hypoxia in human erythroid cells

The 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress 2006

56.

Hypoxia enhances erythroid differentiation of human erythroleukemia cells through an autocrine mechanism of Transforming Growth Factor β1

The 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress 2006

57.

ヘムオキシゲナーゼの発現抑制とその生理的意義

第3回Heme Oxygenase研究フォーラム 2006

58.

低酸素適応におけるヘムオキシゲナーゼ2の役割

第30回日本鉄バイオサイエンス学会シンポジウム 2006

59.

Augmented ventilatory responses to hypoxia and hypercapnia in black-eyed white Mitf mutant mice

The 13th meeting of the European Society for Pigment Cell Research 2006

60.

Lipocalin-type prostaglandin D synthase as a potential tumor suppressor of human melanoma

The 3rd International Symposium (COE). Novel perspectives in cancer research and translation to the clinics. 2006

61.

SOX10 regulates the endothelin receptor type B gene in human melanocyte-lineage cells

第20回日本色素細胞学会年次学術大会 2006

62.

Dynamic changes in expression of heme oxygenases in mouse organs during hypoxia

日本分子生物学会2006フォーラムMolecular Biology-the next Decade-Conference and Scientific Exhibition 2006

63.

Hypoxia and inflammatory cytokines induce expression of adrenomedullin, a potent vasodilator peptide, through separate mechanisms in cultured human tumor cells

日本分子生物学会2006フォーラム:Molecular Biology-the next Decade-Conference and Scientific Exhibition 2006

64.

Hypoxia induces hemoglobin production in human erythroleukemia cells by increasing the secretion of transforming growth factor -β1 and the expression of mitoferrin.

48th Annual meeting of American Society of Hematology 2006

65.

Erythroid-specific 5-aminolevulinate synthase (ALAS2) as a key regulator for the terminal differentiation of erythroid cells

7th International Porphyrin-Heme Symposium 2005

66.

Effects of hypoxia and inflammatory cytokines on endothelin-1 expression in T98G glioblastoma cells

Ninth International Conference on Endothelin 2005

67.

SOX10 regulates the endothelin B receptor gene through the two alternative promoters

19th International Pigment Cell Conference 2005

68.

Twist in the mitf story learned from the shout of black-eyed white mice

19th International Pigment Cell Conference 2005

69.

Hypoxemia associated with blunted hypoxic ventilatory responses in mice lacking heme oxygenase-2: Heme oxygenase-2 as an oxygen sensor

第78回日本生化学会大会 2005

70.

Microphthalmia-associated transcription factor regulates the expression of lipocalin-type prostaglandin D2 synthase, a novel melanocyte marker

第78回日本生化学会大会 2005

71.

Distinct expression profiles of heme oxygenases in the mouse organs during acclimatization to hypoxia

The second International Symposium (COE) 2005

72.

Lipocalin-type prostaglandin D synthase is regulated by microphthalmia-associated transcription factor

第19回日本色素細胞学会年次学術大会 2005

73.

Lipocalin-type prostaglandin D synthase as a melanocyte marker regulated by Mitf

第28回分子生物学会年会 2005

74.

Erythroid-specific 5-aminolevulinate synthase (ALAS2) as a key regulator for the terminal differentiation of erythroid cells

7th International Porphyrin-Heme Symposium 2005

75.

Effects of hypoxia and inflammatory cytokines on endothelin-1 expression in T98G glioblastoma cells

Ninth International Conference on Endothelin 2005

76.

SOX10 regulates the endothelin B receptor gene through the two alternative promoters

19th International Pigment Cell Conference 2005

77.

Twist in the mitf story learned from the shout of black-eyed white mice

19th International Pigment Cell Conference 2005

78.

Hypoxemia associated with blunted hypoxic ventilatory responses in mice lacking heme oxygenase-2: Heme oxygenase-2 as an oxygen sensor

第78回日本生化学会大会 2005

79.

Microphthalmia-associated transcription factor regulates the expression of lipocalin-type prostaglandin D2 synthase, a novel melanocyte marker

第78回日本生化学会大会 2005

80.

Distinct expression profiles of heme oxygenases in the mouse organs during acclimatization to hypoxia

The second International Symposium (COE) 2005

81.

Lipocalin-type prostaglandin D synthase is regulated by microphthalmia-associated transcription factor

第19回日本色素細胞学会年次学術大会 2005

82.

Lipocalin-type prostaglandin D synthase as a melanocyte marker regulated by Mitf

第28回分子生物学会年会 2005

83.

Suppression of Erythroid-Specific 5-Aminolevulinate Synthase Using Short-interfering RNA Alters Iron Metabolism and Inhibits Terminal Differentiation of Human Erythroleukemia Cells

The 46th Annual Meeting for American Society of Hematology 2004

84.

Suppression of Erythroid-Specific 5-Aminolevulinate Synthase Using Short-interfering RNA Alters Iron Metabolism and Inhibits Terminal Differentiation of Human Erythroleukemia Cells

The 46th Annual Meeting for American Society of Hematology 2004

85.

Transcriptional repression of human heme oxygenase-1 gene: Molecular basis and physiological implications

Home Oxygenase: Regulation, Function & Clinical Application 2003

86.

OTX2 regulates expression of DOPAchrome tautomerase in human retinal pigment epithelium

第76回日本生化学会年会 2003

87.

Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells

第76回日本生化学会年会 2003

88.

網膜色素細胞における転写因子機能制御ネットワーク

第17回日本色素細胞学会 2003

89.

Transcriptional repression of human heme oxygenase-1 gene: Molecular basis and physiological implications

Home Oxygenase: Regulation, Function & Clinical Application 2003

90.

OTX2 regulates expression of DOPAchrome tautomerase in human retinal pigment epithelium

第76回日本生化学会年会 2003

91.

Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells

第76回日本生化学会年会 2003

92.

網膜色素細胞における転写因子機能制御ネットワーク

第17回日本色素細胞学会 2003

共同研究・競争的資金等の研究課題 (41)

1.

日本学術振興会 科学研究費助成事業 挑戦的萌芽研究

視細胞を守護する網膜色素上皮細胞の恒常性維持機構の解明

柴原 茂樹 , 武田 和久 , 古山 和道 , 吉澤 美季

挑戦的萌芽研究 (2012-04 - 2014-03)

2.

日本学術振興会 科学研究費助成事業 基盤研究(C)

調節性へムプールの変化に即応するためのヘム生合成調節機構の解明

古山 和道 , 柴原 茂樹 , 金子 桐子

基盤研究(C) (2011 - 2013)

3.

日本学術振興会 科学研究費助成事業 基盤研究(C)

赤芽球型アミノレブリン酸合成酵素の翻訳後修飾とその役割

古山 和道 , 柴原 茂樹

基盤研究(C) (2008 - 2010)

4.

文部科学省 21世紀COEプログラム

シグナル伝達病の治療戦略創生拠点

代表者:菅村和夫

(2003 - 2008)

5.

日本学術振興会 科学研究費助成事業 基盤研究(C)

プロスタグランジンD2による色素細胞の分化・増殖制御機構

武田 和久 , 柴原 茂樹

基盤研究(C) (2006 - 2007)

6.

日本学術振興会 科学研究費助成事業 特定領域研究

肺がんの進展に関与する肺循環血流の制御機構の解明

柴原 茂樹 , 古山 和道 , 丸山 芳夫

特定領域研究 (2006 - 2007)

7.

日本学術振興会 科学研究費助成事業 基盤研究(C)

ヘム合成と分解の複合的調節機序と関連疾患群の病態の解明

古山 和道 , 柴原 茂樹 , 張替 秀郎

基盤研究(C) (2005 - 2006)

8.

日本学術振興会 科学研究費助成事業 基盤研究(B)

低酸素感知機構の分子基盤の解明と換気応答の制御法の開発

柴原 茂樹 , 飛田 渉 , 古山 和道 , 武田 和久

基盤研究(B) (2004 - 2006)

9.

日本学術振興会 科学研究費助成事業 特定領域研究

肺がんの発生と進展に関与する肺特異的低酸素応答の分子機構の解明

柴原 茂樹 , 古山 和道

特定領域研究 (2005 - 2005)

10.

日本学術振興会 科学研究費助成事業 基盤研究(C)

呼吸中枢異常や概日リズム異常を呈する、転写因子MITF変異マウスの病態の解析

武田 和久 , 柴原 茂樹

基盤研究(C) (2004 - 2005)

11.

日本学術振興会 科学研究費助成事業 萌芽研究

肺特異的低酸素応答と換気・血流比維持機構の解明

柴原 茂樹 , 飛田 渉 , 古山 和道

萌芽研究 (2004 - 2005)

12.

日本学術振興会 科学研究費助成事業 特定領域研究

腫瘍の形成と維持を規定する低酸素応答の分子基盤

柴原 茂樹 , 古山 和道

特定領域研究 (2003 - 2003)

13.

日本学術振興会 科学研究費助成事業 基盤研究(C)

サイクリックAMP応答配列を介するWntシグナル伝達系の解析

武田 和久 , 柴原 茂樹

基盤研究(C) (2002 - 2003)

14.

日本学術振興会 科学研究費助成事業 萌芽研究

睡眠時無呼吸に対する防御機構としての低酸素応答の分子基盤

柴原 茂樹 , 武田 和久 , 飛田 渉 , 高橋 和広

萌芽研究 (2002 - 2003)

15.

日本学術振興会 科学研究費助成事業 基盤研究(B)

ポルフィリン系薬剤の毒性評価法確立および低毒性抗癌剤の開発

藤田 博美 , 五十嵐 和彦 , 柴原 茂樹 , 佐藤 治男 , 小川 和宏

基盤研究(B) (2001 - 2003)

16.

日本学術振興会 科学研究費助成事業 基盤研究(B)

低酸素応答の新たな転写制御機構の解析と低酸素の病態における機能の探索

高橋 和広 , 武田 和久 , 藤井 義明 , 柴原 茂樹

基盤研究(B) (2001 - 2003)

17.

日本学術振興会 科学研究費助成事業 特定領域研究(C)

網膜色素上皮細胞におけるWntシグナル関連転写因子群の機能発現機構

柴原 茂樹 , 武田 和久

特定領域研究(C) (2001 - 2001)

18.

日本学術振興会 科学研究費助成事業 特定領域研究(A)

色素細胞分化におけるWntシグナル関連因子とMITFとの機能的相互作用

安元 研一 , 武田 和久 , 柴原 茂樹

特定領域研究(A) (2000 - 2000)

19.

日本学術振興会 科学研究費助成事業 特定領域研究(A)

マラリアの重症化に関与する宿主因子の分子制御

柴原 茂樹 , 武田 和久

特定領域研究(A) (1999 - 1999)

20.

日本学術振興会 科学研究費助成事業 萌芽的研究

腸管筋層における転写因子MITF isoformによるC-KIT発現調節

大井 龍司 , 安元 研一 , 仁尾 正記 , 柴原 茂樹

萌芽的研究 (1998 - 1999)

21.

日本学術振興会 科学研究費助成事業 基盤研究(B)

小眼球症関連転写因子の構造的及び機能的多様性の分子機構

柴原 茂樹 , 安元 研一 , 高橋 和広

基盤研究(B) (1998 - 1999)

22.

日本学術振興会 科学研究費助成事業 基盤研究(C)

神経系組織におけるヘムオキシゲナーゼの生理機能の解析

高橋 和広 , 柴原 茂樹

基盤研究(C) (1997 - 1998)

23.

日本学術振興会 科学研究費助成事業 基盤研究(B)

遺伝子導入によるがん熱中性子捕捉療法の適応拡大

三嶋 豊 , 福森 義信 , 吉野 和夫 , 小野 公二 , 柴原 茂樹 , 玉木 紀彦 , 新津 洋司郎

基盤研究(B) (1997 - 1998)

24.

日本学術振興会 科学研究費助成事業 萌芽的研究

個体老化のモデルとしての白髪形成の分子機構の解明

柴原 茂樹 , 安元 研一 , 高橋 和広

萌芽的研究 (1997 - 1998)

25.

日本学術振興会 科学研究費助成事業 基盤研究(B)

色素細胞の分化調節機構の解明

柴原 茂樹 , 高橋 和広 , 安元 研一

基盤研究(B) (1996 - 1997)

26.

日本学術振興会 科学研究費助成事業 基盤研究(A)

単一細胞における遺伝子発現の新しい解析法の開発と医学的応用

柴原 茂樹 , 安元 研一 , 高橋 和広 , 柴田 孝史

基盤研究(A) (1995 - 1996)

27.

日本学術振興会 科学研究費助成事業 重点領域研究

ヒトヘムオキシゲナーゼ遺伝子の熱ショックエレメントの機能の抑制

藤田 博美 , 柴原 茂樹

重点領域研究 (1995 - 1995)

28.

日本学術振興会 科学研究費助成事業 重点領域研究

神経線維腫症1型の原因遺伝子産物の新しい生理機能の解明

柴原 茂樹 , 吉沢 美季 , 高橋 和広

重点領域研究 (1995 - 1995)

29.

日本学術振興会 科学研究費助成事業 重点領域研究

ヒト ヘムオキシゲナーゼ遺伝子の熱ショックエレメントの機能の抑制機構

藤田 博美 , 柴原 茂樹

重点領域研究 (1994 - 1994)

30.

日本学術振興会 科学研究費助成事業 国際学術研究

ヘム代謝の調節とその先天異常の分子生物学的解析

柴原 茂樹 , 佐々 茂 , 山本 雅之 , HARTMUT Beug , 藤田 博美 , 近藤 雅雄

国際学術研究 (1993 - 1994)

31.

日本学術振興会 科学研究費助成事業 重点領域研究

ヒトヘムオキシゲナーゼ遺伝子の熱ショックエレメントの機能の抑制機構

藤田 博美 , 柴原 茂樹

重点領域研究 (1993 - 1993)

32.

日本学術振興会 科学研究費助成事業 重点領域研究

アルビニズム(先天性白皮症)の本態に関する分子生物学的研究

柴原 茂樹 , 鈴木 裕行 , 富田 靖

重点領域研究 (1993 - 1993)

33.

日本学術振興会 科学研究費助成事業 一般研究(C)

チロシナーゼ陰性型白皮症の病因であるチロシナーゼ遺伝子の異常についての研究

富田 靖 , 柴原 茂樹 , 松永 純

一般研究(C) (1992 - 1992)

34.

日本学術振興会 科学研究費助成事業 重点領域研究

アルビニズム(先天性白皮症)の本態に関する分子生物学的研究

柴原 茂樹 , 鈴木 裕行 , 冨田 靖

重点領域研究 (1992 - 1992)

35.

日本学術振興会 科学研究費助成事業 重点領域研究

アルビニズム(先天性白皮症)の本態に関する分子生物学的研究

柴原 茂樹 , 富田 靖 , 鈴木 裕行

重点領域研究 (1991 - 1991)

36.

日本学術振興会 科学研究費助成事業 一般研究(B)

生体防御反応としてのヘムオキシゲナ-ゼ遺伝子の転写誘導

柴原 茂樹 , 福士 靖江 , 石沢 志信

一般研究(B) (1990 - 1991)

37.

日本学術振興会 科学研究費助成事業 一般研究(C)

チロシナ-ゼ陰性型白皮症の原因であるチロシナ-ゼ遺伝子の異常についての研究

富田 靖 , 柴原 茂樹 , 松永 純

一般研究(C) (1990 - 1990)

38.

日本学術振興会 科学研究費助成事業 がん特別研究

ヒト白血病細胞におけるヘム分解の調節機構

柴原 茂樹 , 福士 靖江 , 石沢 志信

がん特別研究 (1990 - 1990)

39.

日本学術振興会 科学研究費助成事業 一般研究(C)

平滑筋の化学的興奮性受容体の新しいKイオンチャネルの開閉とその制御機構

猪又 八郎 , 江刺 正喜 , 柴原 茂樹

一般研究(C) (1989 - 1989)

40.

日本学術振興会 科学研究費助成事業 がん特別研究

がん細胞におけるヘムオキシゲナーゼ遺伝子の発現に関する研究

柴原 茂樹 , 石沢 志信 , 福士 靖江

がん特別研究 (1989 - 1989)

41.

日本学術振興会 科学研究費助成事業 一般研究(C)

チロシナーゼcDNAを用いた先天性白皮症の遺伝生化学的研究

富田 靖 , 柴原 茂樹

一般研究(C) (1988 - 1988)

Works(作品等) (11)

1.

ヘム分解の制御に関する研究

2013 - 2016

2.

肺特異的低酸素応答と換気・血流比維持機構の解明

2011 -

3.

肺循環血流の制御と換気応答の分子基盤の解明

2011 -

4.

シグナル伝達病の治療戦略創生拠点

2003 - 2008

5.

メラノサイト由来リポカリン型プロスタグランジンD合成酵素が関与する皮膚組織の恒常性維持機構

2006 - 2007

6.

低酸素応答の分子機構の解明と制御法の開発

2002 - 2003

7.

メラニンモノマーの生理活性に関する研究

1999 -

8.

NOと臓器障害

1996 - 1997

9.

ヒト白血病細胞におけるヘム分解の調節機構

1991 - 1992

10.

メラニン生合成の調節

1991 - 1992

11.

ストレスによるヘム分解の調節機構

1989 - 1990

所属する学会

日本生化学会東北支部

International Federation of Pigment Cell Societies

日本色素細胞学会

日本生化学会

日本色素細胞学会(2003/11-2006/11 会長)

International Federation of Pigment Cell Societies(2008/05-2011/09 会長)

日本色素細胞学会(2007/01- 2015/11理事)

日本生化学会(2001/11- 評議員)

日本分子生物学会(1990/04-)

日本色素細胞学会(1989/12- 評議員)

日本生化学会東北支部(2003/04-2005/03 支部長)

日本生化学会東北支部(1989/04-2014/03 評議員)

International Federation of Pigment Cell Societies(2000/11-2014/09 理事)

日本色素細胞学会(2000/11-2003/11 事務局長)

日本生化学会(2002/04-2004/03 編集委員)

日本生化学会(1994/09-1996/09 理事)

日本内分泌学会

日本生化学会東北支部

International Federation of Pigment Cell Societies

日本色素細胞学会

日本生化学会

日本色素細胞学会(2003/11-2006/11 会長)

International Federation of Pigment Cell Societies(2008/05-2011/09 会長)

日本色素細胞学会(2007/01- 2015/11理事)

日本生化学会(2001/11- 評議員)

日本分子生物学会(1990/04-)

日本色素細胞学会(1989/12- 評議員)

日本生化学会東北支部(2003/04-2005/03 支部長)

日本生化学会東北支部(1989/04-2014/03 評議員)

International Federation of Pigment Cell Societies(2000/11-2014/09 理事)

日本色素細胞学会(2000/11-2003/11 事務局長)

日本生化学会(2002/04-2004/03 編集委員)

日本生化学会(1994/09-1996/09 理事)

日本内分泌学会

受賞歴 (3)

1.

日本色素細胞学会

名誉会員 2016-12

2.

Seiji Memorial Lecturer 2005

3.

Takeuchi Medal 2002

担当科目

大学院

運動・スポーツ医科学特講

学部共通

学習基礎教養演習

体育学科     

健康福祉学科

キャリアプランニング,免疫・薬理学

運動栄養学科

解剖・生理学II,生化学,生化学実験,解剖・生理学実験,

スポーツ情報・マスメディア学科

現代武道学科

子ども運動教育学科